Breast Cancer Perioperative Tcm Syndrome Type Standardization And Validation Studies

[Objective] Establish perioperative stage of breast cancer syndrome differentiation n orms based on expert opinion by Delphi expert consultation, and verify the clinical ap plicability and rationality by clinical symptoms epidemiological survey in order to wid ely promoted the TCM syndrome type specification of perioperative stage of breast ca ncer.[Method] Collect information on TCM syndrome type of perioperative stage of bre ast cancer based on Documentary Research Method.Then design the Expert Questionna ire for the consultation by twice expert advices and then systematically analyse the res ults of the consultation. Use the Variable statistical methods such as full score ratio.ra nk sum, Unimportant percentage,synergistic coefficient,the questionnaire internal consiste ncy reliability index etal to Screen and sort the Questionnaire TCM syndrome type an d syndromes,finally formation of standard on the TCM syndrome type specification of perioperative stage of breast cancer.After that conduct Clinical syndromes epidemiolog ical survey on perioperative stage of breast cancer, Use the SPSS software to collate da ta,analy the data with Hierarchical cluster analysis to verify the the clinical utility of t he syndrome standard.[Result]30consultants Composed by breast disease experts, cancer subjects experts and diagnostics of Chinese medicine experts those who have high representative and authoritative in the subject area.Expert consultation results show that:Syndrome type of breast cancer after surgery are:Spleen and stomach qi deficiency, both blood and qi deficiency, both qi and yin deficiency, liver-qi stagnation, qi deficiency and blood stasis; Syndrome type of postoperative adjuvant chemotherapy composed of Spleen and stom ach qi deficiency, both qi and yin deficiency, both blood and qi deficiency, yang defici ency of spleen and kidney; Syndrome type of postoperative adjuvant radiotherapy comp osed of both qi and yin deficiency, yin deficiency fire poison, deficiency of liver-yin a nd kidney-yin. Collect63cases of breast cancer after cases, then analy the data with Hierarchical cluster analysis, we found the result of the syndrome based on liver-qi st agnation,spleen and stomach qi deficiency, both qi and yin deficiency. k-center clusterin g result show:the amount of both qi and yin deficiency syndrome is10(15.87%), live r-qi stagnation syndrome is19(30.15%), spleen and stomach qi deficiency syndrome is34(54.0%). Then count the amount of the tongue and pulse variable on these three sy ndromes. We found patient with qi and yin deficiency syndrome show red tongue less moss take80%, thin and weak pulse take90%; patient with liver-qi stagnation syndro me show th-in coating on the white take84.21%, pulse string or astringent take94.74%;patient with spleen and stomach qi deficiency syndrome show tongue fat side have teeth marks take44.12%, weak pulse take82.35%.From our research, we found that the syndrome type of breast cancer after surgery derived from the Delphi expert advice and Clinical epidemiological survey are the sam e.[Conclusion] In this study, the syndrome type specification of perioperative breast cancer has been Obtained after two rounds of the consultant, and epidemiological inve stigations of breast cancer after surgery. A comprehensive analysis of two-part study th at clinical epidemiological survey and Delphi expert advice obtained breast cancer afte r certificates are basically the same. The results of the Delphi consultation fully reflec ts the expert clinical experience and knowledge derived from perioperative of breast c ancer syndrome type results are reliable.