| Objective Observe pre-diabetes crowd TCM clinical syndrome distribution characteristics, Observe Chinese medicine yiqi nourish blood capsule on people with pre-diabetes type2diabetes outcome influence, and to its security assessment, and to get the drug pre-diabetes intervention on clinical evidence.Method (1) Observe101cases of people with pre-diabetes TCM clinical symptoms and signs,according to the standard on syndrome differentiation and classification, Analysis each TCM syndrome type of body mass index (BMI),waistline,hip circumference, waist-hip ratio (WHR), OGTT blood glucose,OGTT insulin level,glycated hemoglobin (HbAlc), blood fat (TC, TG, LDL-C,HDL-C), thus observe pre-diabetes crowd TCM clinical syndrome distribution characteristics.(2) Using the prospective, randomized, controlled clinical trials of parallel method and make64cases the pre-diabetes patients were randomly divided into two groups.there are33cases in treatment group (Lifestyle intervention+Traditional Chinese medicine yiqi nourish blood capsule, five goals each time, three times a day) and other31patients in the control group (Lifestyle intervention). After the observation period, the treatment group and control group each have lost five patients were followed up.There are26cases in treatment group and control group are28. Observe Chinese medicine yiqi nourish blood capsule on people with pre-diabetes type2diabetes outcome influence and to BMI, waistline.hip circumference,WHR, OGTT blood glucose, and OGTT insulin levels,HbAlc, blood fat, etc’s influence.Result (1)In101patients with pre-diabetes crowd, TCM clinical symptoms appear frequency in order are god fatigue force67cases (66.3%), lumbar debility62cases (61.4%), irritable61cases (60.4%), and the rest of the symptoms appear less frequency, all under50%.(2) According to the standard for the syndrome differentiation classification,and main syndrome types are the deficiency of both qi and Yin blood stasis syndrome43cases (42.6%),Qi deficiency and phlegm-damp24cases (23.8%),Yin deficiency22cases (21.8%), Qi stagnancy12cases (11.9%),and the deficiency of both qi and Yin blood stasis syndrome see most.(3) Compare various syndrome type’s related indicators, Qi deficiency and phlegm-damp group’s BMI, waistline, and Hip circumference, WHR are higher than the other three groups, and the BMI, waistline and WHR compared with the other three groups have differences (P<0.05), Hip circumference in Qi deficiency and phlegm-damp group and the deficiency of both qi and Yin blood stasis syndrome is difference (P<0.05), and the other three groups BMI, circumference of hip and waist,WHR no difference compared (P>0.05).Each syndrome type of the OGTT blood glucose comparison, qi stagnancy group’s FPG,0.5hPG,3hPG are higher than the other three groups, Qi stagnancy compared with the deficiency of qiyin blood stasis syndrome, fasting blood sugar has difference(P<0.05).and compared with Qi deficiency and phlegm-damp syndrome,0.5hPG has difference(P <0.05).and compared with the deficiency of qiyin blood stasis syndrome, Yin deficiency.3hPG all have difference (P<0.05). FINS comparison. Qi deficiency and phlegm-damp syndrome is higher than other three groups, but there were no differences between groups. And the other three groups of0.5hINS and2hINS comparison. Qi deficiency and phlegm-damp syndrome group higher, and there are differences between it and the deficiency of qiyin blood stasis syndrome (P<0.05). Each syndrome type1hINS and3hINS between the comparison of the differences were not (P>0.05).Each syndrome HbAlc was no more difference (P>0.05).Compared TC of each group,the deficiency of both Qi and Yin with blood stasis> Qi stagnancy, Yin deficiency,Qi deficiency and phlegm-damp, there is differences between the deficiency of both Qi and Yin with blood stasis and Qi deficiency and phlegm-damp syndrome (P<0.05).Compared TG of each group, deficiency of both Qi and Yin with blood stasis> Qi deficiency and phlegm-damp, Yin deficiency, Qi stagnancy, there is differences between Qi deficiency and phlegm-damp syndrome and Qi stagnancy (P<0.05).Each group of LDL-C have no statistically significant difference (P>0.05). Compared HDL-C of each group, Qi stagnancy> Yin deficiency, deficiency of both Qi and Yin with blood stasis.Qi deficiency and phlegm-damp. There is statistically significant differences between Qi stagnancy and Qi deficiency and phlegm-damp (P<0.05),(4) Traditional Chinese medicine yiqi nourish blood capsule on people with pre-diabetes type2diabetes outcome influence.1year after treatment, people with pre-diabetes reverse into normal glucose tolerance reversal rate, the treatment group was23.1%vs10.7%in the control group, Into the prevalence of type2diabetes, the treatment group was7.7%vs35.7%in the control group, Between the two groups there was statistically significant difference (P<0.05).(5) After intervention treatment group OGTT points blood sugar levels are down and FPG,2hPG and3hPG comparing with before has statistical significance (P<0.05), The control group FPG,0.5hPG,1hPG,2hPG increase compared with before and3hPG decline but all no difference compared with before.(6) After the intervention of the two groups,FPG and2hPG comparing has statistical significance (P<0.05),0.5hPG,1hPG,3hPG in between the two groups is no difference (P>0.05).After intervention treatment group FINS, compared with before increase, other OGTT points insulin levels decreased, especially in3hINS down the most obvious, and compared with before a difference (P<0.05), The control group after intervention at every point OGTT insulin levels are increased, and no difference with before. Between the two groups after intervention FINS,2hINS,3hINS comparing statistical significance (P<0.05), After intervention between groups0.5hINS,1hINS there were no difference.(7) The treatment group after intervention glycosylated hemoglobin dropped significantly, and intervention former statistical significance was found between (P<0.05), The control group after intervention glycosylated hemoglobin increased compared with before. before and after intervention no difference. Interference between the two groups after HbAlc was significant difference (P<0.05).(8) After the intervention of the treatment group BMI. waist circumference, hip circumference and WHR, compared with before decreased, And compared with before, BMI and hip circumference in on them have difference (P<0.05);After the intervention group BMI, waist circumference, hip circumference and WHR increase compared with before,There is no difference between before and after the intervention (P>0.05);After the intervention of the two groups BMI is different, the rest of the no difference.(9) After intervention treatment group TC, TG, LDL-C are down and HDL-C is increased both which compared with pre-treatment, and before and after intervention LDL-C have significant differences (P<0.05).After the intervention control group TC, TG, LDL-C are increased and HDL-C is down compared with pre-treatment,and before and after intervention TC、LD1-C have significant differences. After intervention between the two groups of comparison,TC and LDL-C have statistically significant difference.but there is no statistically significant difference between TG and HDL-C (P>0.05)Conclusion (1) In pre-diabetes crowd, according to syndrome standard, traditional Chinese medicine clinical syndrome mainly for the deficiency of both qi Yin blood stasis syndrome, Qi deficiency and phlegm-damp, Yin deficiency.qi stagnancy,and the deficiency of both qi Yin blood stasis syndrome most common.(2) traditional Chinese medicine yiqi nourish blood capsule can effectively reduce the people with pre-diabetes blood sugar, reduce glycated hemoglobin, lipid metabolism, to prevent people with pre-diabetes into type2diabetes have better clinical curative effect. Speculate it may be through the.improveβ cell function, the promotion of insulin secretion, increases insulin sensitivity mechanism to play a role. |
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