Rs13124007, Rs6850166, Rs2331142 Polymorphism With The Han Nationality Female Gout Correlation Studies

Objective:To investigate associations between gout and polymorphisms of rsl3124007, rs6850166, rs2231142 in Chinese Han females.Methods:Hardy-Weinberg was used to verify the representativeness of the sample. Specifically amplify the target fragments of GLUT9 gene and ABCG2 gene and genotyping was performed by polymerase chain reaction (PCR) technology. Forther more, the genotype-phenotype correlation analysis was performed bttween the gout patients.Results:①Gout cases and controls are matched by age(P>0.05), the body mass index, waist to hip ratio, systolic blood pressure, diastolic blood pressure, blood glucose, uric acid, triglycerides, blood urea nitrogen and creatinine of gout group are significantly higher than controls(P<0.05).15.45%of gout patients suffer from tophi.②There was a clear link between the gout and rs13124007, rs6850166, rs2231142 and the A allele of rs6850166 and rs2231142 appeared to be the risk allele for susceptibility to gout (p= 0.002, OR 2.31 [95%CI 1.33-4.01]; p< 0.001, OR 1.88 [95%CI 1.35-2.62]),theC allele of rs13124007 in the gout group were significantly higher than the controls(p= 0.034, OR 1.73 [95%CI 1.04-2.89]).②No significant differences of phenotype between individuals carrying the GG,GC and CC genotype in rs13124007 (P>0.05). There are more obesity risk who carrying GA and AA genotype in rs6850166 locus (P= 0.026, OR 0.21 [95%CI 0.04-0.93]; P= 0.041, OR 0.28 [95%CI 0.08-1.01]). There are greater waist-hip ratio in the individuals who carrying the AA genotype comparing CC genotype (P=0.047). Individuals who carrying the AA and CA genotype have higher systolic blood pressure (P= 0.021), uric acid concentration (P= 0.037), triglyceride levels (P= 0.038) and total cholesterol levels (P= 0.012), and comparing with CC genotype, more individuals carrying AA and CA genotype suffering hypertension and diabetes (P= 0.018, OR 0.26 [95%CI,1.17-6.08]; P= 0.041, OR 3.62 [95%CI 0.99-13.18]).Conclusion:The Polymorphisms of rs13124007(G/C), rs6850166(G?A) and rs2231142(C/A) are associated with susceptibility to gout in Chinese Han females and A allele in rs2231142 may be relate to the level of blood pressure, blood glucose and blood lipid between gout patients.