Vertigo Set Preparation Of Particles

[Objective] xuanyundingkeLi GranuLe,which is made from AstragaLus membranaceu,Rhizoma chuangxiong,Chinese angeLica,Radix SaLvia miLtiorrhiza,pueraeia Lobata ohwi and other six kinds of herbs,is an effective prescription in treating seniLe persons in the pattern of qi deficiency and bLood stasis(QDBS),In order to enabLe the prescription exert maximum effect, the authors deveLoped their granuLes, the paper preparation process of a systematic experimentaL study of.[Methods]Using the extraction rate, tanshinoneⅡA, feruLic acid, paeonoL as the index, HPLC was used to Quantitative,OrthogonaL design test method to expLore supercritical CO2 extraction and reflux extraction alcohoL xuanyunDingfang 5 herbs taste the optimum process parameters, and compare the advantages and disadvantages of both approaches. Using the content of puerarin,feruLic acid content as indices, HPLC was used to Quantitative,by OrthogonaL design L9(34) for optimization of extraction craft of xuanyundingkeLi Granule.of the water extract using purified alcohol,vacuum concentration, vacuum drying investigated active ingredients of different temperatures on the impact of.To screen better excipient and better ratio of the excipients and to improve the formability of the xuanyunding granuLe by SingLe-factor.Dynamics modeL was estabLished by determining hygroscopic rate and Critical relative humidity(CRH)of the xuanyunding GranuLe.Hydroscopicity rates were determined and compared.Set up a TanshinoneⅡA, ferulic acid, puerarin HPLC quantitative method and a method of study visits.[Results] The superior SFE-CO2 technology of veitigo were as follow:extracting temperature 40℃extracting time 1.5h,extracting Pressure 35Mpa,co-soLvent was 95% ethanol.The optimum extraction condition is:Not soaking, adds 8 times of quantities and 6 times of quantity water withdraws 1.5h and 1.0h.The best purification process:concentrated Liquid concentration of controL at 1.1～1.15,the concentration of alcohol was 60% alcohol for 12h.60℃decompression dry retention of an active ingredient in most of the loss at Least.The best excipients and its formula were eight extract and three excipients which consisted ofβ-CD,the granule was made by 3%PVPK30.CRH of each prodctiong technoLogy was 60%.the xuanyunding Granule is scheduLed particles at different humidities moisture dynamic equations in line with the compartmentmodel, absorption capacity of 6%corresponds to 56.1% reLative humidity,humidity in the packaging can be saved 11.6h (0.48days). Determination of the active ingredient Ways study findings show that the Linear range, precision instruments, stabiLity, repeatabiLity, recovery etc in Line with the quantitative anaLysis of the requirements.[Conclusions] Optimal process parameters in accordance with vertigo made particLes can set the maximum to ensure the cLinicaL efficacy of this compound, in Line with the quality control of the reLevant provisions of.The process a reasonable, workable, stable, and can be used to quality standards,stability, efficacy, toxicology, clinical research. Quantitative analysis methods (HPLC) rapid, accurate, reliable and can be used to process and stability studies.