Studies On Preparation Craft And Quality Standards For The Maitong Granule

Objective: To establish the preparation craft and quality control standard of Maitong Granule.Methods: L₉(3⁴) Orthogonal design was used to optimize the best extraction craft and the best refined craft of Maitong Granule, and carry on analysis of variance to the result, confirm the experimental parameter finally. In water extraction craft research, the most important influence factor for the extraction quality are extraction times(A), decoction times(B)and adding the amount of water(C), and carry on the investigation with the Salvianolic acid B and total immersion for target, carrying on the craft optimization with the Salvianolic acid B for target in refined craft, making orthogonal experiment for the most factor:relative density(A) , ethanol deposit chroma(B)and ethanol deposit temperature(C). shaping research and screen to this guanule in addition, with shaping, pile density, angle of repose,dissolving, hygroscopicity and borderline relative humidity as the target, invegate the advantages and disadvantages of dextrin, starch, lactose in making guanule, and select the optimum adjuvants which prepare guanule to make up with the comprehensive point system. Investigate and rectify flavor pharmaceutical sodium cyclamate, stevioside and aspartame consumption and mouth feel of candy, and confirmFinally that rectf ies kind of pharmaceutical of flavor and consumption. Regard craft parameter confirmed as the standard, trial produce three batches of pilot scale, and examine it, make the quality stadard of Maitong guanule, offer reasonable feasible technical parameter for great prduction Radix astragali, Radix Salviae miltiorrhizae , Radix paeoniaerubra were identified for qualitative identification by TLC, and the content of Astragaloside in monarch Radix astragali was determined by TLCS, the content of Salvianolic acid B in official drug Radix Salviae miltiorrhizae and Paeoniflorin inadjuvant drug Radix paeoniae rubra were identified by HPLC. Results: The three fators in the craft of water extraction all have influence...