Study On The Correlation Between The Changes Of Tongue Microcirculation And Lung Cancer

Objective: To investigate changes of tongue microcirculation in primarybronchogenic carcinoma patients, and further analysis of tonguemicrocirculation changes of qi deficiency and phlegm dampness, yindeficiency and terrific heat, qi stagnation and blood stasis and deficiency ofboth qi and yin in patients with lung cancer, to provide an objective basis forTCM diagnosis, classification and treatment of early lung cancer.Methods: Refer to seventh edition"department of internal medicine"standard in diagnosis of lung cancer, the Fourth Hospital of Hebei MedicalUniversity (Hebei Provincial Tumor Hospital) province collected140patientswith lung cancer in accordance with the inclusion criteria for period2011.9-2012.10in the department of respiration, according to the situations ofthe patients asked with uniformed observation tables. According to the TCMsyndrome diagnosis of cancer standard in2002edition of"traditional medicineresearch guiding principle"with editor Zheng Xiaoyu, the patients can bedivided into qi deficiency and phlegm dampness, yin deficiency and terrificheat, qi stagnation and blood stasis and deficiency of both qi and yin.Observation of tongue microcirculation changes and30cases of normalcontrol people were compared by using XW-B-3microcirculatory microscopyexamination instrument. Observation items include:1microvascularmorphology:①the microvascular number,②diameter of the input branch,③diameter of the output branch;2nipple state:①the epithelial layerthickness,②the fungiform papilla diameter;3pipe loop shape:①pipe loopdefinition,②abnormal of the loop surrounding;4flow state:①the dottedline shape,②the wire break;5microvessel status:①hemorrhage,②exudative, and to study the changes of the four syndromes. Results:1There are serious tongue microcirculation disorder in patients with lungcancer. Compared with normal control group, lung cancer group patients havesignificant different in microvascular number, epithelial layer thickness, pipeloop definition, abnormal blood flow around the loop, microvascularexudation and hemorrhage (P<0.01). Mainly, the number of microvesselsdecreased significantly; thinning of epithelial layer thickness; pipe loopdefinition in fuzzy, accounted for84.29%, loop surrounding abnormal tospasmand fuzzy proportionlarger, accounted for34.29%,22.86%respectively;blood flow in phantom shapeand wire break dominated, accounted for45%,45.71%respectively; microvascular hemorrhage and exudation, accounted for42.14%,38.57%respectively.2The tongue microcirculation is different in different syndromes of lungcancer patients. Fungiform papilla diameter, epithelial layer thickness,perivascular spasm increase，accounted for60.0%, microvascular exudationincrease，accounted for73.33%in qi deficiency and phlegm dampness group,compared with other groups, there are significant differences (P<0.05).Microvascular number increase, the input branch and output branch ofthickening, blood flow to intermittent shape, accounting for90.0%in yindeficiency and terrific heat group, compared with other groups, there aresignificant differences (P<0.05). The capillary loops and loop ambiguity,microvascular bleeding as the characteristic, pipe loop fuzzy accounted for96.87%, loop ambiguity accounted for78.13%, microvascular bleedingaccounted for75.0%in qi stagnation and blood stasis group, compared withother groups, there are significant differences (P<0.05). Microvascularnumber is the least, input and output branch thinning, fungiform papilladiameter shorting, epithelial thicking (P<0.05), blood flow as the dotted lineshape, accounting for86.84%in the deficiency of both qi and yin, comparedwith other groups, there are significant differences (P<0.05).Conclusions:1There are serious tongue microcirculation disorder in patients with lungcancer. The mechanism may be that respiratory dysfunction, physical dysfunction, such as dispersing and descending function disorder, waterdistribution of body fluid, dereliction of duty and Wei function is not solid,leading to peripheral microcirculation disorder. Mainly for the number ofmicrovessels decreased significantly; thinning of epithelial layer thickness;pipe loop definition in fuzzy; loop surrounding abnormal to spasm and fuzzyproportion larger; blood flow in phantom shape and wire break dominated;microvascular hemorrhage and exudation. This can provide reference indexfor the early detection of lung cancer.2The tongue microcirculation is different in different syndromes of lungcancer patients. In qi deficiency and phlegm dampness group, qi promotingweakness, qi-blood operation impeded, resulting in the tongue of blood stasis,fluid accumulation; qi cannot govern blood, so that it can not in the vein ofnormal operation and overflow pulse; phlegm turbidity and wet cohesive, qi isobstructed, gasification disorders, changes of epithelial cells of tongue down;phlegm main and collateral channels, meridians spasm, so fungiform papilladiameter thickening, epithelial thickness increases, perivascular spasm,microvascular exudation. In yin deficiency and terrific heat group, heatfumigation, qi and blood running speed, the superficial tongue blood flowincreased, and yin fluid deficiency, blood is difficult to continue, theemergence of microvascular number, input, output branch branches thickening,epithelial thickness thinning, flow to break shape characteristics. In qistagnation and blood stasis, qi engine block, running sluggish, essence ofwater and grain material distribution and arrhythmia, blood stasis, blood is notrunning smoothly, tongue dystrophy;"blood stasis does not go, new blooddoes not grow; blood stasis does not go, blood does not return", blood staged,and not abide normal circulation, overflow outside the vessel, so the tube loopand loop ambiguity, microvascular character in bleeding. In the deficiency ofboth qi and yin group, qi promoting weakness, blood less, deficiency of yin,tongue dystrophy; yang unable to stir up the blood, the blood flow sloweddown; qi cannot absorb the blood firmly; deficiency of both qi and yin, tonguedystrophy, breast dysplasia, the input and output branch thinnest and fungiform papilla diameter shortest, epithelial thickness is thin, flowing withdotted line shape is most obvious. This more deeper understanding of essenceof syndrome of lung cancer, and provide some reference for microcosmicsyndrome differentiation of tongue inspection.