A Research Of Lactoferrin Genetic Polymorphisms Of Relationship Between Dental Caries Susceptibility In Yugur And Han Nationality

Objective:Analysis of the association between the polymorphism of the three Single nucleotide site:rs10865941(C/T)、rs1126477(G/A) and rs9110(C/T) which within lactotransferrin (LF) gene and dental caries susceptibility in the population of Han and Yugur nationality.Methods:The author has chosen355samples of Yugur minority and Han people in Gansu Yugur autonomous county to conduct a case-control study of which contains164samples (Han85and Yugur79samples) in case group and191samples (Han86and Yugur105samples) in control group; In addition, analyzing site genotype of three single nucleotide rs10865941rs1126477and rs9110by nucleic acid mass spectrometry technique after extrating DNA from peripheral blood; Finally,making a comparison of three locus genotype frequency, allele frequency distribution of dental caries and healthy samples in Yugur and Han people by chi-square test method and analyzing datas by SPSS16.0statistical software.Results:1)All genotype distribution frequency fits Hardy-Weinberg balance(P>0.05)2)rs10865941SNPs genotype frequencies has statistically significant differences which between the unhealth group and heath group of Han, and rs10865941CT genotype frequency of unhealth group (36.5%) is obviously lower than health group(61.9%) with OR=0.394(95%confidence interval [CI]=0.187-0.828) in Han nationality.3)rs10865941、rs1126477and rs9110genotype frequency of LF has no statistically significant differences in Yugur nationality.Conclusion:The result suggest that it is possible the polymorphisms rs10865941sites of LF is relevant with dental caries susceptibility of the I Ian nationality.