The Angiographic Characteristics And Related Factors Analysis In Elder Male Patients Of Coronary Artery Disease With Different Blood Glucose Levels

Objective To eluciate the influence of blood glucose on the coronary artery disease(CAD) in elder male patients through comparing the clinical features and the angiographiccharacteristics with different blood glucose levels.Methods One hundred and fourteen elder male patients with CAD were dividedinto three groups based on their glucose levels：normal glucose tolerance group (NGT，n=48), impaired glucose regulation group (IGR, n=23) and diabetic group (DM, n=43).The angiography of coronary artery were performed, and the biochemical parameters andclinical characteristics among three groups were compared. The associated factors of CADwere determined with logistic regression analysis.Results The levels of FPG,PPG,HbA1c,UA,ALT,ALP and hs-CRP in DM groupand IGR group were significantly higher than those in NGT group(P <0.05),while thelevels of FPG,PPG,HbA1c,UA, hs-CRP in IGR group were siganificantly lower than thosein DM group(P <0.05).But there were no statistically significant differences in theproportions of aging, smoking history, hypertension history and BMI among threegroups(P>0.05). The prevalence of multiple vessel lesion in diabetic group(83.7%) andIGR group(65.2%) was significantly higher than that in NGT group(41.6%). However,more single vessel lesions were found in NGT group(P <0.05). There was a significanthigher incidence of diffusive lesions in DM group(51.2%) as compared to that in IGRgroup(21.7%) and NGT group(12.5%)(P=0.015, P=0.001). Severe coronary arterialstenosis and complete occlusions occurred more in IGR group(87.0%,26.1%) and DMgroup(95.3%,51.2%) than those in NGT group(52.1%,6.3%). Logistic regression analysisrevealed that FPG, PPG, HbA1c, UA, ALT, ALP, hs-CRP were independent risk factors ofCAD with multiple vessel lesions in elder male patients.Conclusions Coronory artery lesions are more severe in elderly male patients withDM and IGR. Moreover, the incidence of multiple vessel lesions and diffusive lesions are higher in DM and IGR group than that in NGT group. FPG, PPG, HbA1c, UA, ALT, ALP,hs-CRP are independent risk factors of CAD with multiple vessel lesions in elder males.