| Objective：To evaluate the risk factors of atherosclerosis among COPD patients, andto provide a theoretical basis for the effective prevention of cardiovasculardisease in patients with COPD.Methods：A total of130patients diagnosed with COPD (the COPD group) and131health participants (the control group) were enrolled in the study. COPDwas diagnosed by post-bronchodilator spirometry in these patients. Thecarotid intima-media thickness (IMT) was detected and the situation of theformed plaques was recorded in every person. Blood samples were collectedto measure the concentration of total cholesterol (TC), triglyceride (TG),high density lipoprotein cholesterol(HDL-C), low density lipoproteincholesterol (LDL-C), Homocysteine（HCY）, plasma fibrinogen leve（lFIB）,while smoking index was registered at the same time． Multiple regressionanalysis and Pearson correlation was performed to evaluate the correlativefactors of IMT among COPD patients．Results：The thickness of IMT，the detection rate of plaques，and the smokingindex in the patients of the COPD group were significantly higher than thosein the control group (P <0.05)．The level of TC，LDL-C in the patients ofthe COPD group were significantly lower than those in the control group (P<0.05). Multiple regression analysis of IMT about correlative factors among the patients of the COPD group showed that age, FEV1%and TC were inlinear relationship with the thickening of IMT(P <0.05). Pearson correlationanalysis showed that age, smoking index was positively correlated with IMT,and FEV1%was negatively correlated with IMT in patients with COPD.Conclusion：(1) Age is a independent risk factor of atherosclerosis, however thedegree of arterial atherosclerosis could be aggravated in the patients withCOPD.(2) Smoking index might be a risk factor for artery stenosis.(3) Significant negative correlation is found between FEV1%pre andcarotid IMT.(4) Serum LDL-C and TC were not directly related toatherosclerosis, although at a lower level in COPD patients. |
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