Research On Ibuprofen As An Adjunctive Method In The Treatment Of Severe Chronic Periodontitis

Object:Severe chronic periodontitis is a common disease in our country and the control of the periodontal tissue inflammation by only mechanical debridement is often less satisfactory due to lack of efficient adjunctive therapy. Ibuprofen belongs to non-steroidal anti-inflammatory drugs. It can reduce the production of prostaglandin which promotes the alveolar bone absorption, leading to the subtle change of the periodontal micro-environment. From this point, we speculate that ibuprofen may do some good in the periodontal treatment. This study aimed at exploring the role of ibuprofen as an adjunctive method in the treatment of severe chronic periodontitis.Methods:20subjects with severe chronic periodontitis but otherwise health participated in the study and they were divided into two groups randomly. The test group took ibuprofen300mg, bid for5days after scaling and root planing (SRP), while the control group was only conducted SRP. Indexes including probing depth (PD), attachment loss (AL) and bleeding index (BI) were recorded at baseline,1w,2w,4w respectively. Meanwhile, the gingival crevicular fluid (GCF) samples were collected at each time point. The levels of tumor necrosis factor alpha (TNF-a), osteoprotegerin (OPG) and receptor activator of NF-κB ligand (RANKL) in the GCF samples were detected using enzyme linked immunosorbent assay (ELISA). SPSS17.0statistical package was used to analyze the data. The data were shown as mean±standard deviation. One-way ANOVA and least significant difference were used to compare the data at different time in each group. Student’s t test was used to compare different groups at the same time. P<0.05was considered statistically significant.Results:For both the test group and the control group, the probing depth and bleeding index were significantly lower at1w,2w and4w when compared with the data at the baseline. The ELISA results showed the levels of TNF-α in GCF were significantly lower at1w,2w and4w than the data at the baseline. There were no differences between different time for the attachment loss and the levels of RANKL, OPG and RANKL/OPG. At same time point, both the clinical data, the levels of TNF-α, RANKL, OPG and RANKL/OPG for the test group and the control group were not statistically significant.Conclusion:1. SRP shows some efficacy in the treatment of chronic severe periodontitis.2. SRP can improve the inflammatory micro-environment in severe periodontitis, but it is of not much value in the alveolar bone remodeling.3. Ibuprofen shows no positive effect for the treatment of severe chronic periodontitis.