The Correlation Between Amino Acid Neurotransmitter And Insomnia Of Liver Depression And Qi Stagnation Symptoms And The Intervention By Supplemented Bupleurum Liver-coursing Powder

Objective:In recent years, with increasing social pressures, theaccelerated pace of life, and the deterioration of theenvironment, and other reasons, the incidence of insomnia isincreasing year by year, in clinics and wards, we found a lotof liver disease often associated with insomnia symptoms causedby this phenomenonour attention, I feel it is necessary toexplore the link between liver disease and insomnia. TheNeijing "Lingshu God" mentioned in the liver blood, bloodScotia soul."Puji skill side Volume I" discusses the causesof insomnia that:"The level of human liver is not evil, it islying goes to the liver, God static derived sleep soundly thisliver evil, the soul shall any, is lying is the soul of Youngvitro.[1]visible sleep quality and physiological functions ofthe liver is closely related to, in order to further investigatethe mechanism of liver disease and insomnia, we conducted aseries of studies, that the topics based on Chinese medicinebiological basis of the theoretical discussion of the "liver blood, blood Scotia soul insomnia (national Natural scienceFoundation, the Fund Code: No.30973687). This article is basedon a research branch of the subject. This article aims toexplore the correlation of the amino acid neurotransmitter withchronic hepatitis B liver Qi stagnation, insomnia andobservation the Modified CHAIHUSUGAN powder on the liver Qistagnation insomnia intervention.Methods：1Collected in the outpatient and ward60patients met theinclusion criteria liver Qi stagnation insomnia patients, andthe other in the hospital the families and college studentscollected30cases of healthy people, as the blank control group,three group members Inquirer fillthe tables collected sleepquestionnaire, the scale of the Pittsburgh Sleep quality Index(PSQI), anxiety, self-assessment scale (SAS), self-RatingDepression scale (SDS) record, records of patients of insomniacharacterized by Inquirerintegral with liver Qi stagnationpermit individual symptom scores, and the consent of thesubjects and informed consent in the case, the detection ofglutamate (Glu) and gamma-aminobutyric acid (GABA).2of the60patients were randomly divided into thetreatment group and the comparison group,30cases in eachtreatment group and the comparison group in age, sex, diseaseduration, the Pittsburgh Sleep Quality Index (PSQI), anxiety,self-rating scale index (constitute SAS), depression andself-assessment index (SDS), of insomnia characterizedintegral and liver Qi stagnation single symptom score was nosignificant difference (P <0.05) than the previous. Give TCMtreatment group the flavored CHSGS, twice a day, western medicine control group estazolam tablets1mg once daily, blankcontrol group not administered. After the end of a course oftreatment (4weeks), be a review of glutamate andgamma-aminobutyric acid levels, and once again recorded thesubjects of the Pittsburgh Sleep Quality Index (PSQI)Self-Rating Anxiety Scale Index (SAS), Self-Rating Depressionvolume index (SDS), insomnia characterized integral andHepatic Qi Stagnation individual symptom scores, in order toobserve the amino acid neurotransmitters and liver Qistagnation insomnia and flavored CHAIHUSUGAN powder on theliver Qi stagnation insomnia intervention effect.Result1amino acid neurotransmitters and liver Qi stagnationinsomniaDifferent ages, patients of different gender amino acidneurotransmitter levels are not the same, the difference wasstatistically significant (P <0.05) the youth and middle-agedpatients with amino acid neurotransmitter decline than theelderly increase, suggesting that young adultpatients morelikely to suffer from insomnia, liver Qi stagnation; amino acidneurotransmitter decline of female patients than male patientsincrease, prompted the female patients were more likely tosuffer from liver Qi stagnation insomnia. Sleep Scale index isalso related to the amino acid neurotransmitter, of the SRSSPoints, PSQI integral, SAS Credits, SDS integral higher aminoacid the lower class neurotransmitters difference wasstatistically significant (P <0.05), compared with otherpatients. Difficulty falling asleep, more than a dream, wakingthree symptoms of insomnia characterized integral increases as the main symptoms of patients with amino acid neurotransmitterlevels higher than the other patients, the difference wasstatistically significant (P <0.05). Individual symptom scoresof liver Qi stagnation, XiongXie fullness pain, belching,emotional depression three integral increased mainly inpatients with amino acid neurotransmitter higher than otherpatients, the difference was statistically significant (P<0.05).2The Modified CHAIHUSUGAN scattered liver Qi stagnationinsomnia interventionAfter a course of treatment, the treatment group glutamicacid decreased significantly compared to the comparison group,the gamma-aminobutyric acid increased significantly comparedto the comparison group, the difference was statisticallysignificant (P <0.05), the prompt flavored CHAIHUSUGANscattered reduceglutamate and γ-amino butyric acid is superiorestazolam sheet. Sleepiness Scale index of the two groups ofpatients after treatment than before treatment, which theflavored CHAIHUSUGAN scattered on the improvement of the SleepScale Index better than estazolam tablets After treatment, theamount of sleep the table index difference was statisticallysignificant (P <0.05). Integral characteristics of the twogroups of patients with insomnia after treatment is lower thanbefore treatment the flavored CHAIHUSUGAN better thanestazolam tablets scattered on the improvement of the sleepcharacteristics integral, sleep characteristics integralAfter treatment, the difference was statistically significant(P <0.05). Flavored CHSGS treatment of patients with singlesymptom score significantly lower than before treatment, estazolam tablets in the treatment of patients did not changesignificantly, improve the symptoms of liver Qi stagnation,flavored CHAIHUSUGAN San superior estazolam tablets,statistically significant differences between the two groups.(P <0.05)ConclusionThis study observed the flavored CHSGS and estazolamtablets in the treatment of liver Qi stagnation insomnia,changes in amino acid neurotransmitter levels before and aftertreatment, the Pittsburgh Sleep Quality Index (PSQI),Self-Rating Anxiety Scale Index (SAS), depression andself-assessment index (SDS), of insomnia characterizedintegral and liver Qi stagnation changes in individual symptomscores, analysis of various indicators of changes in amino acidneurotransmitter liver Qi stagnation insomnia,specificperformance, young adult, female patients of aminoacid neurotransmitters; Pittsburgh sleep Quality Index (PSQI),anxiety, self-rating scale index (SAS), the self-ratingdepression volume index (SDS) in patients with high aminoacidamino acid neurotransmitter higher levels ofneurotransmitters; to difficulty falling asleep, more than adream, waking three symptoms of insomnia characterizedintegral elevated as the main symptoms of the patients;XiongXie pain, fullness, belching, emotionaldepressionitemsintegral elevated mainly in patients with highamino acid neurotransmitter.On the Modified CHAIHUSUGAN scattered liver Qi stagnationinsomnia intervention superior estazolam tablets, insomnia andtotal efficiency to improve insomnia characterized Points, reduce Insomnia Scale index, improve liver Qi Stagnation singlesymptom score, etc. superior to estazolam tablets.