| Objective:Compare the clinical curative effect of Aidi Injection withcombination chemotherapy of Paclitaxel and Nedaplatin and purechemotherapy of Paclitaxel and Nedaplatin in treatment of advancedepithelial ovarian carcinoma postoperatively，then evaluate thefunction and curative effect of Aidi Injection in advancedepithelial ovarian cancer.Methods:1.We chose56patients with chemotherapy who had been diagnosedas advanced ovarian epithelial carcinoma postoperative ingynecology tumor ward and Oncology Ⅳ ward of taihe hospital inJune2010and March2013. We hypothesized that the survival periodsof the patients would be more than6months.According to thepiecewise random grouping and block randomized method,the selectedcases can be divided into the treatment group with30cases and thecontrol group with26cases.2. The patients in the control group were treated with the TPchemotherapy (Taxol,135mg/m2,ivdrip; Nedaplatin,60mg/m2, ivdrip).The patients in the treatment group were treated the TP chemotherapyas the same as the control group,but at the same time, the patients in the treatment group were treated with Aidi Injection (50ml,ivdrip, once per day, stay for a week). The Aidi Injection containsacanthopanax、ginseng、astragalus and blister beetle. Patientsundergo a chemotherapy every four weeks, each patient received atleast2cycles of chemotherapy. Compared two groups of patients withadverse reaction after chemotherapy (include reaction ofgastrointestinal tract, Inhibition of bone marrow, damage of liverand kidney function)，the change of the KPS score before and afterthe treatment, weight changes before and after the treatment,recenttreatment effect.We collected the data and analyzed it,then weevaluated the efficacy of Aidi Injection.Results:1. Compare the curative effect of two groups of patients:Allpatients underwent239times of chemotherapy, The control group had111cases and the treatment group has128cases.There were31caseswho had appeared greater than or equal to Ⅱlevels ofgastrointestinal tract reaction in the control group,and thetreatment group had19cases.The control group had63cases who hadappeared Ⅱ level or higher suppression of bone marrow, and thetreatment group had46cases. There were13cases whose damagefunction of liver were greater than or equal to Ⅱlevels, and thetreatment group had6cases. There were12cases whose damagefunction of kidney were greater than or equal to Ⅱlevels, and thetreatment group had5cases.The treatment group in thegastrointestinal tract reaction, suppression of bone marrow,function damage of liver and kidney are lower than those in controlgroup, the difference was statistically significant(p<0.05).2. Compare the changes in quality of life before and after chemotherapy of the two groups: There were27%cases whose qualityof life had gone down in the control group after chemotherapy, thereare only16.4%in the treatment group. The descent rate of thequality of life in control group is greater than the rate oftreatment group, the difference was statistically significant(p<0.05).3. Compare weight change before and after treatment in twogroups, there were5cases who gained weight in the control group,11cases whose weight were steady,10cases of weight loss; and therewere10cases who gained weight in the treatment group,16caseswhose weight were steady,4cases of weight loss. The rate of weightloss in the control group is greater than the rate in treatmentgroup,the difference was significant difference (p<0.05).4. Compare the recent treatment effect of the two groups:Thetotal remission rate of the control group is61.5%; and the rateis86.7%in the treatment group.The total remission rate in thetreatment group is higher than the control group, the differencewas statistically significant (p<0.05).Conclusion:Aidi Injection can enhance the curative effect of thechemotherapeutics and it can weaken the toxic reaction of thechemotherapeutic accordingly improving patient’s quality of life. |
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