Effects And Mechanism Of Shenguibaoganshengbaidanbai Pills On Expeirmental Hepatic Cin+iosis In Rats

Cirrhosis of the liver is a chronic progressive liver disease, is caused by a varietyof causes for a long time or a few times and the diffuse liver damage. Cirrhosis of theliver is usually composed of deterioration of liver fibrosis, Hepatic fibrosis by theliver more increase in extracellular matrix (ECM) synthesis in the liver caused by thedegradation ability at the same time, the ECM deposition in the liver, therefore, causefiber connective tissue proliferation, then the liver fibrosis. Liver fibrosis continues toworsen, fiber forming, hepatic lobule structure was damaged and form false flocculus,eventually formed in the process of deformation and hardening liver, liver cirrhosis.According to the statistics, our country is the world’s highest incidence, mortality,cirrhosis, and liver cirrhosis is hard to cure, only for clinical liver cirrhosis caused bythe disease to symptomatic treatment, strive to relieve symptoms. Although livertransplantation is a solution to this conundrum breakthrough, however, due to the highcost and the difficulty of matches, many limiting factors, not widely used.Shenguibaoganshengbaidanbai pills (SGP) by personal for the monarch drug in aprescription, medicine deer glue, tortoise plastron and glue with "make". Ginseng as amonarch drug in a prescription, in the body on the other hand, ginseng saponins canbake the centralizer, enhance the body’s immune system, which is a two-wayadjustment, Match with medicine deer glue, tortoise plastron and glue, to achieve thepurpose of illnesses in addition to evil.In this article, through subcutaneous injection of CCl4corn solution at the sametime involved in alcohol, high-fat-low-protein feed, experimental cirrhosis in ratsmodel was established successfully. To fill the stomach approach to medicine, giverespectively SGP1g/kg,2g/kg,4g/kg. At the same time set up3.3g/kg Weiganfutaitabellas (WGT) as the Positive medicine group, the blank group and the Model groupto compare. Observe the SGP for liver cirrhosis in rats liver pathological morphologyand liver coefficient, further testing of cirrhosis rats portal venous pressure (PVP),toresearch SGP for liver cirrhosis with portal hypertension treatment, and at the same time to detect the liver cirrhosis in rats albumin (ALB), albumin/globulin (A/G),bilirubin (BIL), hydroxyproline(Hyp), to study if SGP to liver function recovery effect,if play a role to improve the function of liver protein synthesis, excretion function ofliver and if SGP could reduce liver Hyp, inhibit collagen synthesis and deposition. Inaddition, we also research the function of SGP palying on Red blood cell (RBL),Mean corpuscular volume (MCV), Red Cell Distribution Width-standard deviation(RDW-SD), hemoglobin(HGB), Mean Corpuscular Hemoglobin (MCH), MeanCorpuscular Hemoglobin Concentration(MCHC), Platelets(PLT), Mean PlateletVolume(MPV), platelet distribution width(PDW), Platelet cubic thrombocytocrit(PCT) to investigate whether SGP anemia treatment cirrhosis of the liver.When cirrhosis of the liver blood circulation disorder, blood vessels narrow,distorted and losts normal blood vessels adjacent to the structure, those lead to theformation of a portal hypertension. Portal hypertension serious degree reflects thedegree of liver cirrhosis.This experiment shows that, SGP1g/kg,2g/kg,4g/kg andWGT can all significantly reduce portal hypertension. Prompt SGP has reduced therole of cirrhotic portal hypertension.Cirrhosis formed, liver dysfunction, causing decompensation of liver function,reduce liver protein synthesis ability, ALB reduce, A/G reduce even convert.Nowadays,we use ALB, A/G to reflect the actual status of the liver. This experimentshows that, SGP4g/kg has obvious difference on the elevation of ALB and A/G.Prompt SGP has the curative effect of reducing cirrhosis of the liver caused byalbumin.The liver pathological changes of liver excretion, secretion and detoxificationability to diminish. The liver discharging capacity decreases, BIL increases and goesin serum. This experiment shows that, SGP1g/kg,2g/kg,4g/kg and WGT can allsignificantly reduce BIL. Prompt SGP can increase the liver into the dischargecapacity, reduce BIL.Cirrhosis formed, ECM is generated and stored in large quantities. The livercollagen hyperplasia, so in the liver tissue, collagen metabolites Hyp increase. Thisexperiment shows that， SGP1g/kg,2g/kg,4g/kg and WGT can all significantlyreduce Hyp. Prompt that SGP can reduce the content of Hyp in liver tissue.Liver disease anemia more decrease when seen in chronic hepatitis, cirrhosis inliver. The incidence of anemia can be as high as75%, and accounted for when liver blood abnormalities, and is acted in blood cells reduce, hemoglobin and plateletreduction. This experiment shows that SGP2g/kg,4g/kg and WGT can allsignificantly increase RBC, reduce MCV and reduce RDW-SD. Prompt SGP decreaseof red blood cells of liver cirrhosis, and abnormal red blood cell anemia symptomshave certain treatment function reduce, hemoglobin and platelet reduction of bloodcells. Only SGP4g/kg can at the same time has obvious rise of HGB, MCH, MCHC.Prompt SGP decrease of hemoglobin of cirrhosis of the liver has a certain therapeuticeffect. SGP2g/kg,4g/kg can obviously elevate the four parameters of platelet. WGThas no obvious effect. Prompt SGP for cirrhosis of the liver caused bythrombocytopenia has certain therapeutic effect, and is better than WGT.From what has been discussed above, compared with general resistance tocirrhosis of the liver, SGP can reduce portal hypertension of cirrhosis rats, increasealbumin excretion function, raise liver transformation. For the treatment of anemia inliver cirrhosis, prompt SGP has development and utilization value for treatment ofliver cirrhosis.