The Expression Of Caspase-2and The Relationship With Liquefaction Degeneration Of Basal Cell In Lichen Planus

Caspase Family is the key enzyme in the process ofapoptosis，caspase-2is a highly conserved but functionally poorlydefined member of the caspase family，and it is involved in celldeath, inflammation, and differentiation.Lichen planus is a chronicor subacute inflammatory skin diseases， civatte bodies andliquefaction degeneration of basal cell is one of its typicalhistopathological features.The pathogenesis of Lichen planus is notclear.The role of caspase-2in the pathogenesis of lichen planus isworthy of further study.Objective:To explore the expression of caspase-2in lichenplanus and provide a theoretical basis to further clarify thepathogenesis of lichen planus.Methods: Formalin-fixed, paraffin-embedded tissue blocks,including28cases of lichen planus and8cases of normal skintissue, collected in the Second Hospital of Jilin Universitydermatology clinic.We apply immunohistochemical methods todetect the expression of caspase-2and use the statistical softwareto analysis the differences of the expression in the above twogroups. Results: Caspase-2was expressed in all28samples of lichenplaus, of which24cases were strongly positiveexpression.Caspase-2positive granules was observed in eachlayer of the epidermis except the cuticle, and it also be detected inthe inflammatory infiltration of superficial dermal.There are eightcases of normal skin tissue as a control group，the expression ofcaspase-2in six of them was positive，and the rest two cases werenegative.Through statistical analysis, we found that the expressionlevels of caspase-2in lichen planus is significantly higher than innormal skin tissue.Conclusion:1),Lymphocyte infiltration was found at the junctionof the dermis and epidermis.2), Caspase-2expressed in themajority of normal skin tissue, mainly located in the basal layer ofthe epidermis, it may be involved in the normal differentiation ofkeratinocytes cells.3),The expression of caspase-2is stronglypositive in every layer of the epidermis except the cuticle，and theexpression levels of caspase-2in lichen planus is significantlyhigher than in normal skin tissue.It may play an important role in theoccurrence and development of lichen planus through apoptosisand cell cycle arrest.