| ObjectivesThe aim of this study is to determine the seroprevalence of hepatitis C virus (HCV),hepatitis B virus (HBV) and syphilis in HIV-1infected subjects and related risk factors inShandong province. Besides, to explore the related progressive factors to AIDS in HIV-1infected subjects.MethodsA retrospective investigation including the general situation of the study (name, gender,education level, occupation, marital status), and high-risk behavior history of exposure(previously paid to donate blood/plasma history history of MSM, history of intravenousdrug users.history of blood transfusion or history of extramarital sex, etc.) and thecorresponding physical examination was conducted in eligible subjects who lived inShandong province of China between2000and2010. All subjects included in the studywere tested for the presence of anti-HCV antibody, HBsAg and anti-TP (Treponemapalladium) antibody after informed consent. Excell2003was used to establish a databaseand SPSS13.0was used for statistical analysis.Results1. The seroprevalence of HCV, HBV and syphilis in HIV-1infected subjects1.1The general seroprevalence of HCV, HBV and syphilisAmong2087HIV infected subjects, anti-HCV antibody was present in41.2%, HBsAgin12.6%and anti-TP in19.6%, respectively.1.2The seroprevalence of HCV, HBV and syphilis in different ways of HIV-1infections.The prevalence co-infected with HIV-1and HCV in former paid blood donors (FBD),injection drugs users (IDUs), blood transfusion recipients, heterosexuals and men who have sex with men (MSM) was50.0%,45.2%,49.5%,36.3%and24.3%,respectively(p<0.001). In HIV-HBV co-infectors, the prevalence was11.8%,14.6%,12.6%,11.9%,14.3%, respectively(p=0.566), and in HIV-syphilis co-infectors, theprevalence was15.1%,16.0%,10.7%,17.8%,23.0%, respectively (p<0.001).1.3The annual prevalence of HIV-1infected subjects co-infected with HCV, HBV orsyphilisThe prevalence of HCV-HIV co-infected patients was significant difference (p<0.001)among these years and slight decline. The serial prevalence of co-infection with HIV andHCV decreased from70.5%before2003to32.4%in2010. Similarly, the prevalence ofsyphilis-HIV co-infected patients was also significant difference (p=0.008), however, withseveral years declining, the rates of syphilis have increased from recent years. ForHBV-HIV co-infection, there was no statistical difference (p=0.132) observed in our studyamong years.2The risk factors of infected HCV, HBV, TP in HIV-1infected subjectsMultivariate logistic regression was applied for the HCV, HBV and syphilis groupincluding analysis of age group, sex, occupation, HIV status, marital status, race andeducation degree. Besides, two out of HCV, HBV and syphilis would be defined as riskfactors when another was selected as dependent variable.Multivariate analysis revealed that males were more likely to be HIV-HCV co-infectionthan females in HIV patients. Han seems to be subject to HCV infection. Compared to2010, the HIV patients were more possible HCV cases and those who were infected withHIV through blood routes (including FBD, IUDs, blood transfusion recipients) were morelikely to be anti-HCV antibody positive. Beside of HCV status, The MSM andheterosexual who were HIV positive were more likely to be anti-TP positive than othersubgroups Risk factors in our study failed to show association with HBV serostatus.3Impact factors of the progression of the disease in HIV-infected individuals3.1Multiple linear regression analysisThe number of CD4+T cells was used as dependent variables and gender, age, ethnicity,marital status, education level, route of infection of HCV, HBV and TP infection status asindependent variables. Stepwise selection was used in the multivariate logistic regressionand the entry probability for stepwise was0.05, the removal0.1.Multiple linear regression analysis showed that HCV infection, gender and HIV homosexual transmission was the impact factor.3.2A single, multi-factor logistic regression analysis when disease state as thedependent variablesMultivariate analysis showed that age, Han nationality, the different modes oftransmission, and marital status are independent risk factors in progression to AIDSpatients.3.3The impact on the length of the incubation period in different AIDS patientsT (F) test was used to anlyze the impact on the length of the incubation period indifferent AIDS patients. The test results showed no significant difference. Conclusion1Co-infection with HCV, HBV or syphilis is frequently observed in all describesubgroups of HIV infection2The prevalence of HCV, HBV and syphilis in different ways of HIV-1infections wadifferent.3HCV infection rates have a declining trend over time; HBV infection rate was nsignificant change; TP has an upward trend in recent years.4Between HCV infection and TP infection have correlation.5HCV infection accelerated CD4cell apoptosis in HIV infected individuals.Co-infection with HCV, HBV and syphilis is frequently observed in all... |
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