Study On The Rule Of Traditional Chinese Medicine Syndromes And Treatment Of Anovulatory Infertility

ObjectiveTo explore the distribution rule of traditional Chinese medicine (TCM) syndromes of patients with anovulatory infertility and the relationships of sex hormone and metabolic parameters with various TCM syndrome types of anovulatory infertility.MethodsQuestionnaire survey and serum testing including luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), prolactin (PRL), sex hormone-binding globulin (SHBG), fasting blood sugar (FBG), fasting insulin (FINS), total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and leptin in103patients with anovulatory infertility and20healthy fertility women were determined respectively. Among anovulatory infertility patients,30patients were classified by TCM syndrome differentiation as spleen deficiency type,48as liver deficiency type, and25as kidney deficiency type.76patients in103anovulatory infertility patients were treated with the appropriated Chinese medicine for3months. And anthers6months were following up to get the conception rate.Results1. The kupperman score of anovulatory infertility patients showed the highest was the liver deficiency group, and the lowest was the kidney deficiency group.2. FINS, HOMA-IRI, Leptin, TC, TG, LDL, T, PRL, LH level in the case group were higher than the control group (p<0.01-0.05). SHBG level was lower in the case group than the control group (p<0.01).3. FINS, HOMA-IRI in the spleen deficiency group were higher than the liver deficiency group and the kidney deficiency group (p<0.05); PRL in the liver deficiency group was higher than the spleen deficiency group and the kidney deficiency group (p<0.01); LH in the kidney deficiency group was higher than the spleen deficiency group (p<0.05). There were not significant different among the levels of T, Leptin, TC, TG, LDL, SHBG.4.76patients who got the TCM treatment,24patients concept in3months and17patients concept in6months after treatment.5. In the spleen deficiency group, FINS、HOMA-IRI were decreased significantly; PRL was decreased in the liver deficiency group, but the change wasn’t significantly; LH in the kidney deficiency group were decreased significantly.Conclusion1. The main TCM syndrome differentiation among anovulatory infertility patients is the liver deficiency type.2. The higher level of FINS, HOMA-IRI, Leptin, TC, TG, LDL, T, PRL, LH and the lower level of SHBG maybe the common pathological syndrome in different TCM types. Meanwhile various TCM types have different endocrine and metabolic characteristics.3. TCM treatment can help regulate the endocrine and metabolic characteristics, as well as induce ovulation effectively in patients with anovulatory infertility.