Efficacy Analysis Of The Internal Iliac Artery Infusion Chemotherapy For Locally Advanced Cervical Cancer

Cervical cancer is one of the most common malignant tumor ofgynecology and obstetrics, is also one of the most common cause offemale cancer deaths. High incidence of situ carcinoma range30-35years,invasive carcinoma range50-55years. Cervical cancer is2nd incidence inwomen’s cancer in the world，even in developed countries, roughlyone-third in patients with cervical cancer deaths due to lesions can not becontrolled. Current treatment is surgical and radiation therapy for cervicalcancer, and secondary to chemotherapy and other treatments. When mostpatients who have metastatic, or loss of opportunity of surgery andradiotherapy patients, systemic chemotherapy become importanttreatments of chemotherapy. Locally advanced cervical carcinoma refersto the tumor diameter>4cm, IB2-IVA stage bulky cervical cancer instages. Surgery and radiotherapy for the women with early cervicalcancer are effective, but to the young women with cervical cancer, nodoubt are more suitable to surgical treatment. And for locally advancedcervical cancer, since larger lesions, the difficulty of surgical therapy alsoincreases. Neoadjuvant chemotherapy is a conventional treatment methodin nearly30years, aimed at making the tumor to shrink, achieve thepurpose of surgical resection. Including neoadjuvant chemotherapy with intravenous systemic chemotherapy and arterial catheterization(interventional therapy).Internal iliac arterial infusion chemotherapy isthe most common method in the interventional therapy for cervical cancer.This article collected65patients with locally advanced cervical cancerduring March2008to October2012, all of them can not receive surgicaltherapy. Rely on retrospective comparative methods of analysis, lookingfor a suitable internal iliac arterial infusion chemotherapy method forcervical cancer.Objective: Through the comparison of two kinds of cervical cancerinternal iliac arterial infusion chemotherapy methods to assess thefeasibility of treatment for cervical carcinoma and its clinical application.Methods: I collected65patients with locally advanced cervicalcancer during March2008to October2012, into33cases of continuouschemotherapy infusion groups, one shock chemotherapy infusion groupof32cases. All patients with a cervical biopsy before treatment,continuous chemotherapy infusion group of27cases of squamous cellcarcinoma, adeno-carcinoma in6cases. One shock chemotherapyinfusion groups with24cases of squamous cell carcinoma,adenocarcinoma in8cases. Therapeutic regimens of one shockchemotherapy infusion group therapeutic regimens: According to tumorsize to distribute drugs,60-120mg paclitaxel, carboplatin100-200mgrespectively on the left and right common iliac artery sequencechemotherapy infusion within30minutes. Therapeutic regimens of continuous chemotherapy infusion group: After local anesthesia usingbilateral internal iliac arterial catheter. Using catheter sheaths, Super slidewire and COBRA angiography catheters, COBRA catheter stay within thebilateral internal iliac artery, respectively. After the success of bilateralinternal iliac artery catheter, paclitaxel100-200ml60-120ml5%glucosedissolved in solution, respectively, on the left and right common iliacartery while pumping, the duration is6hours, and carboplatin100-200ml100-200mg5%glucose dissolved in solution, respectively, on the left andright iliac artery injection, the duration is4hours. One shockchemotherapy infusion group used same drug and dose to continuouschemotherapy infusion group, compared two groups of women withcervical cancer lymph node metastasis after resection and short-termeffect rate, resection rate and long-term survival of1-3years.Result: The two methods can make the tumor size reduce, the effectof the continuous chemotherapy infusion group is higher than the oneshock chemotherapy infusion group（P <0.05)，the internal iliac arterialcontinuous infusion group surgery rates are higher than one shockchemotherapy infusion group,91%and53%，respectively. Postoperativepathological examination revealed that pelvic lymphatic metastasis ofcontinuous chemotherapy infusion group was significantly lower thangroup the one shock chemotherapy infusion group (P <0.05).There is noconsiderable distinction between two groups to survival rate of one ortwo years,94%and90%,85%and78%,respectively,but there is difference between two groups to survival rate of three years, continuouschemotherapy infusion group(82%)is higher than one shock chemotherapyinfusion group (53%)(P <0.05).Conclusions:1.The internal iliac arterial continuous chemotherapyinfusion group, and one shock chemotherapy infusion group can maketumors shrink, the combination of paclitaxel and carboplatin is effective.2. The internal iliac arterial continuous infusion group lymphaticmetastasis and tumor regression rate is lower than one shockchemotherapy infusion group.3. After interventional therapy for unablesurgical patients can get surgery opportunity, the internal iliac arterialcontinuous infusion group surgery rates are higher than one shockchemotherapy infusion group.4. The survival of3years of the internaliliac arterial continuous chemotherapy infusion group is higher than oneshock chemotherapy infusion group, internal iliac arterial infusionchemotherapy in the treatment of locally advanced cervical cancer is asecure and valuable manner.