Analysis Of Clinical Effect And Mechanism Of Applying Stretta Radiofrequency To Treat Reflux-induced Asthma

ObjectiveBy analyzing and comparing the three groups of patients includinggastroesophageal reflux disease, allergic asthma and reflux-induced asthma,investigate the effect and mechanism of Stretta RF treatment on asthmainduced by gastroesophageal reflux disease.MethodsTo August2010to May2011,60patients in our hospital GastroesophagealReflux Disease Center were for experimental primary object. including age,gender and general symptom score, endoscopyimpedance, esophagealmanometry and other tests to elect the60cases diagnosed as GERD patients,and is divided into20cases of gastrointestinal symptoms of GERD group,20cases of reflux-induced asthma group,20cases of both allergic asthma andGERD group. Analysis and comparison of three groups of patients with sputumeosinophilic granulocytes and the proportion of neutrophils, peripheral bloodeosinophilic granulocytes percentage of cells, lung function, peak expiratoryflow (PEF); three groups of patients underwent the Stretta radiofrequencytreatment, after treatment Half-yearly endoscopy, impedance, esophagealmanometry, the objective of each review item line statistical analysis.Results1. Induced sputum cytology, reflux asthma group and the AS combinedGERD group neutrophil cells, the percentage of eosinophils than a simple GERD group was significantly higher. Reflux asthma group compared with theAS merger GERD group, the neutrophil percentage was significantly highereosinophil percentage to reduce the differences were statistically significant.2.Than a simple merger GERD group percentage of eosinophils in theperipheral blood examination, AS GERD group and reflux asthma wassignificantly higher, the difference was statistically significant.3.Six months after Stretta RF treatment follow-up, patients withreflux-induced asthma symptom score decreased the extent and the remissionrate was significantly better than the other two groups (P<0.05). Comparison ofthe review project, the three groups of impedance check the Z2channels (ie,LES15cm) reflux total percentage of reflux DeMeester points and pH≤4in thetotal detection percentage of time were significantly reduced (P<0.05), threegroup of the lower esophageal sphincter pressure, reduce the incidence ofesophagitis, but the difference was not statistically significant (P>0.05). Refluxasthma group and the AS merger GERD group PEF were significantly improved,and reflux asthma group the degree of improvement was significantly betterthan the after group (P<0.05).Conclusions1.Reflux-induced asthma,, airway inflammation is mainly in the neutrophilinflammatory infiltration, significantly different from allergic asthma mainly byinfiltration of eosinophils; can be induced sputum cytology cytology andperipheral The percentage of blood eosinophils used in the identification ofreflux asthma and allergic asthma.2.Endoscopic Stretta RF treatment by reducing the height of the reflux,blocking the neural mechanisms and reduction of transient lower esophagealsphincter relaxation mechanism to effectively control the reflux, the treatment ofreflux asthma a safe and effective method.