Professor Cui Hongsheng's Medication Rules And Experience In The Treatment Of Bronchial Asthma And Gastroesophageal Reflux Disease

Research background:ln gastroesophageal reflux disease(GERD)prevalence rate is 2.5%?7.8%,as the population ages,the increasing prevalence of overweight and obesity,GERD diagnostic rate increases,the prevalence has a rising trend year by year,and Bronchial asthma,Bronchial asthma,BA)in patients with GERD incidence is 43%?82%,significantly higher than the general population.Based on reverse flow both physical damage,micro suction,esophagus bronchus reflection,airway neurogenic inflammation,airway reactivity,pressure change and drug factors such as mechanism,influence each other,and asthma with GERD is"Refractory asthma(Refractory asthma,RA)" one of the important reasons.The treatment of BA combined with GERD(BA/GERD)in western medicine was significantly affected by"treatment by division".The general principle of internal medicine treatment is anti-inflammatory,antispasmolysis and antiasthmatic combined with long-term anti-acid treatment.The disadvantage is that long-term use of bronchodilators and corticosteroids in asthma patients will induce or aggravate reflux.On the other hand,acid-inhibiting therapy can only reduce the acid concentration,but has no effect on reflux itself and non-acid reflux.Moreover,long-term use of PPI has the risk of drug interaction and lung infection,which is not conducive to the control of asthma.The Chinese medical community also has the above characteristics,and the positioning,primary and secondary issues are not clear after the merger of the two,and the pathogenesis and treatment are lack of overall understanding.Professor cui hongsheng,the supervisor,based on the holistic view of traditional Chinese medicine,syndrome differentiation of viscera and shaoyang cardinal theory,combined with the pathogenesis characteristics after the merger of the two,proposed that the core pathogenesis of BA/GERD is "loss of harmony of viscera,stagnation of qi and adverse cardinal".Research purpose:to investigate the etiology and pathogenesis characteristics of BA/GERD,summarizes the mentor and the cardinal differentiation theory,provide reference for treatment of traditional Chinese medicine "complications".Research methods:(1)formulate relevant phrases such as asthma related phrases:cough,cough,rinse,choke,To gasp,gasp,gasp,shortness of breath,Xiao,Chest tightness.Reflux symptoms related phrases:spit acid,swallow acid,attracted ghosts,alas vinegar there,alas acid,suffused with the evil hey there full,travel in the hot,food certification,bitter,acid,acid regurgitation,ou ou salivary decay,heartburn,pique,eh,Hui etc.in the traditional Chinese medicine resources net,the Chinese medical search relevant prescriptions,frequency analysis,using the theory of traditional Chinese medicine,in order to help clinical(2)using the SPSS Modeler 18 to conform to the supervisor of the discharge standard prescription frequency analysis,clustering analysis and difference analysis,draw the frequency chart,network diagram,clustering tree,combining with related reading teacher shi clinic study.(3)combined with cui,a professor at the previous research,typical medical record,mentor guidance experience summarizedResults:a total of 42 prescriptions were included in the ancient prescriptions.Those that met the expected target were renshui jindan and xingjiao drink.The other prescriptions were asthma and acid vomiting related prescriptions.End into the formulas tutor's 103 prescriptions,it is concluded that the second-order,third-order and fourth-order table and five order drugs.The network was associated with 16 groups of drug pairs.Aggregate into five categories.Based on the clinical classification of GerdQ scores had no significant difference between various types of asthma.Research conclusions:Bronchial asthma combined concept exploration for gastroesophageal reflux disease,need to clarify the orientation and characteristics of the pathogenesis in TCM,mentor proposed BA/GERD belong to a special form of "xiao",prompt when from the combination of Chinese and western medicine theory,based on the combination of macro and micro,give priority to with xiao disease treatment,and each other-give attention to two or morethings to treatment and the cardinal throughout,respectively from cardinal not hold,cardinal,cardinal disadvantageous,cardinal on syndrome differentiation,clinical effect is remarkable,tutor experience in traditional Chinese medicine overall governance thought,dialectical prescription medicine has a unique characteristics,it has reference significance for syndrome differentiation of traditional Chinese medicine compound disease.