Clinical Research For The Measurement Of Auditory Event-related Potential With Different Sound Stimuli

Objective1. To research the auditory event-related potentials (AERPs) evoked by pure-tone and different Chinese speech (including single-syllable words, two-syllable words and numbers) stimuli respectively. Meanwhile, to explore feasibility of using different Chinese speech forms as stimulation to evoke AERP in Chinese people.2. To compare differences of the waveforms of auditory event-related potentials (AERPs) when stimulated by pure-tone and three different Chinese speech forms with the optimum intensity, the mean incidence rates, latencies and amplitudes of AERPs were analyzed, the waveforms of AERPs were quantitatively scored. Then the relationship between stimuli and the waveforms of AERPs were statistically explored;3. To study the differences of the waveforms of auditory event-related potentials (AERPs) evoked by different sound stimuli between left and right hemispheres. Meanwhile, to verify the theory of words advantage hemisphere and explore the relationship between stimuli and the different speech processing. MethodsThe Chinese word cards (including single-syllable words, two-syllable words and numbers) according to the characteristics of Mandarin, requirements of speech audiometry and sound stimuli were screened. Each card as speech audiometry signal software was edited after stereo-recording, montaging and transforming, which should be compatible with the current equipment used by now. Target stimulation and non-target stimulation were selected randomly, test intensity was set at60dBSL AERPs were measured in37young normal post-graduated students (70ears) with pure-tone and three different Chinese speech forms as stimuli. The typical wave P1, Nl, P2, N2and P3of AERPs could be recorded and quantitatively scored, then the mean incidence rates, latencies, amplitudes and scores of AERP evoked by different sound stimuli were compared each other. To analyze whether the differences of P300evoked by different sound stimuli were also present in between the ears around. Meanwhile, to compare the waveforms of auditory event-related potentials (AERP) evoked by different sound stimuli between left and right hemispheres and explore the relationship between stimuli and the different speech processing.ResultsThe typical waveforms of AERPs could be recorded by both pure-tone and three different Chinese speech stimuli, the differences were statistical significance among the four groups (X2=9.046, P=0.029), in which the Chinese two-syllable word was more likely to evoked AERP than pure-tone, which remains of Chinese speech forms, and the differences were statistical significance (X2=7.992, P=0.005<0.05/6,6represented the numbers of comparison). The quantitative scores and amplitudes of P3evoked by pure-tone and three different Chinese speech stimuli were showed no significant difference (the former F=1.795, P=0.496; the latter F=0.800, P=0.496) among different stimuli. But on the whole, the waveforms of AERPs were smoother and much satisfied evoked by Chinese character and two-syllable word than pure-tone and Chinese number stimuli. The latencies of P3evoked by four kinds of different stimili were significant difference (F=5.088, P=0.005), in which it was significant longer by numbers stimuli than by other one (P<0.05). Nevertheless, the amplitudes of P3were no significant differences mong the four groups (P>0.05). There were24cases in four different sound stimulus could be recorded of typical AERPs waveforms about two ears. The latencies of N2and P3, the amplitudes of N2-P3of the above waveforms were compared respectively. The results indicated that the latencies of P3and N2recorded of the left ear were significant differences among the four groups (the former F=3.489, P=0.020; the latter F=8.343, P=0.000). However, this kind of situation did not exsit in the right ear. In addition, there were no significant differences of the amplitudes of N2-P3among the each group between around our ears (the left ear F=1.690, P=0.177; the right ear F=1.644, P=0.187).Conclusions1. Besides pure-tone and Chinese single-syllable words, other Chinese speech such as two-syllable words and numbers could be used to evoke AERP with satisfied waveforms, which indicates that the Chinese character, two-syllable words and numbers were available to apply for AERP measurement as stimuli for Chinese people;2. When with the optimum intensity stimuli, the typical waveforms of AERPs could be recorded by both pure-tone and three different Chinese speech stimuli, in which the Chinese two-syllable words was more likely to evoked AERP than pure-tone;3. According to all data and waveforms, wo could see that the waveforms of AERPs were smoother and much satisfied evoked by Chinese character and two-syllable words than pure-tone and Chinese numbers stimuli;4. The latencies of P3were significant differences among each stimuli, which showed that the latencies of P3evoked by number stimuli were significant longer than by other stimuli, but the amplitudes of P3were no significant differences each other;5. The latencies of N2and P3were significant differences among each stimuli in left ear, which showed that the latencies of N2and P3evoked by number stimuli were significant longer than by other stimuli. Nevertheless, the other compositions of AERP were no significant differences each other in right ear;6. Whether speech stimulation or pure-tone stimulation, the left hemisphere in word processing process were at an advantage, but it was not absoluteness and only one for processing advantage hemisphere. They were the coordination and mutual compensation in speech processing.