Study On Sodium Pyruvate Correcting Acdosis And Proecting The Fuctions Of Organs In Hemorrhagic Shock

Hemorrhagic shock is one of the leading causes of death among trauma patients, andit can induce metabolic acidosis and multiple organ dysfunction. Sodium pyruvate solutioncontaining pyruvate ion has not only the effect of correcting metabolic acidosis caused byhemorrhagic shock but also the function of organ protection. However, the study ofinfusion of isotonic solutions containing different doses of sodium pyruvate on correctingacidosis and protecting organ effects has not been reported. In this study, a model of ratwith severe hemorrhagic shock was established. The effects of different doses of sodiumpyruvate on acid-base balance, tissue oxidative stress and inflammatory injury of thesevere hemorrhagic shock rats were compared through detecting the arterial blood gas, theconcentration of serum insulin, the concentration of serum lactate and pyruvate, the lactatepyruvate ratio, the concentration of tissue malondialdehyde, and the level of tissueinflammatory factor.The results show that different doses of sodium pyruvate can ameliorate metabolicacidosis caused by severe hemorrhagic shock, and its ability to correct acidosis isincreased significantly as the dose of sodium pyruvate increased, but it induces alkalosiswhen the dose exceed a certain limit.180min after the infusion of135mg/kg sodiumpyruvate, the pH values return to the baseline level, and the base excess values andbicarbonate concentrations do not return to baseline levels;180min after the infusion of396mg/kg sodium pyruvate, the pH values increase significantly compared with thebaseline level, and the base excess values and bicarbonate concentrations do not changesignificantly form the baseline values; Infusion of1220mg/kg sodium pyruvatesignificantly increases the pH values, the base excess values and bicarbonateconcentrations, so it can induce alkalosis.Infusion of low-dose sodium pyruvate increases oxidative stress in hepatic tissueand inflammatory injury in small intestinal. Infusion of medial-dose sodium pyruvate orhigh-dose sodium pyruvate can decrease oxidative stress and inflammatory injury in tissue.Oxidative stress in hepatic tissue is increased by infusion of different doses of sodiumpyruvate; Oxidative stress in small intestinal tissue is decreased by infusion of396mg/kg sodium pyruvate, and infusion of1220mg/kg sodium pyruvate decrease oxidative stressin small intestinal and lung tissue. Infusion of135mg/kg sodium pyruvate increasesinflammatory injury in small intestinal tissue, but it can inhibit inflammatory injury inrenal and lung tissue; Inflammatory injury in renal, small intestine and lung tissue areinhibited by infusion of396mg/kg or1220mg/kg sodium pyruvate.