Effect Of Preeclampsia On Fetal Lung Maturity

Objective：To observe the effect of preeclampsia on fetal lung maturity.Methods：The Wistar pregnant rats were randomly divided into control group and modelgroup which were intraperitoneal injected with L-NAME. At the20th day of pregnencyfetal rats lung was taken out and divided into two parts: the first part was dyed with HEstaining and observed with microscope, while the second part was used for extracting RNAwhich was tested with Real-timePCR to detect HIF-1alpha, VEGF, SP-B and SP-C mRNAexpression.Results： HE staining shows that the pulmonary vascular and trachea development ofpreeclampsia preterm group is better than that of normal premature group; Real-time PCRof tissue indicates that HIF-1alpha, VEGF, the SP-B and SP-C mRNA expression level innormal full-term group is higher than that in both normal preterm group and preeclampsiapreterm group (P <0.05); HIF-1alpha and VEGF mRNA expression level in preeclampsiapreterm group is higher than that in normal preterm group(P <0.05)；Preeclampsia pretermgroup compared with normal preterm group has no significant difference in the SP-B andSP-C mRNA expression level(P>0.05).Conclusion：Preeclampsia can accelerate the structure maturity of the fetal lung, but ithas no significant effect on alveolar function.