The Relationship Between Syndrome Of Blood Stasis And Diabetic Kidney Disease Patients And The Effect Of PGE1Treatment

Objective:To investigate the relationship between blood stasis syndrome(BSS) and diabetic kidney disease(DKD), and compare the effect of treatment with PGE1.Methods:Choose30cases of normal physical examination and140cases of patients with diabetes mellitus (DM). The patients were divided into group A and B (group A are DMs accompanying with DKD,100cases; group B are DMs without DKD,40cases). These Patients are categoried by the diagnostic code of IDF2005for DM and Mogensen for DKD. Evaluate the patients according to the blood stasis syndrome score. Analysis the different score of DKD in different stage. With the median (21) of group A’s score as border classifying A into two groups. Analysis the blood stasis syndrome and BP, eGFR,24hUpro,D-Dimer,Scr and PTGER2mRNA expression of the relationship. In group A selection in DKD Ⅱ,Ⅲ,Ⅳ stage (namely trace proteinuria period and clinical proteinuria period) patients80cases were randomly divided into two groups,reatment group and control group),each40cases. Compared to two groups of patients before and after treatment the eGFR, MAP,24hUpro, D-Dimer,Scr, blood stasis syndrome score, PTGER2mRNA expression change. And further discussed the blood stasis syndrome score and detect each index correlation between.30persons of normal physical examination and140patients with DM were selected in the study. The patients were divided into two groups. Group A consisted100cases of DM accompanying with DKD, and group B of another40cases without it. The patients with DM were diagnosed according to the IDF2005diagnostic standard and DKD to the Mogensen standard. ALL were scored by Blood Stasis Syndrome Degree sheet(BSSS) and were compared with each other to find their differences.80patients of DKD Ⅱ,Ⅲ,Ⅳ stage from group A were randomly divided into treatment group and control group, of40cases respectively, which treatment group were treated with PGE1,10ug/day, for2weeks duration. MAP, eGFR,24hUpro, D-Dimer,Scr, BSSS, mRNA expression of PTGER2were investigated before and after treatment. Results:1. The BSSS of patients is significantly higher than normal persons (p<0.01), and which of group A is higher than group B(p<0.05).2. Analysis blood stasis syndrome scores of the different stages of the DKD patients. All of them are significant differences between the groups (p<0.01). It shows that the BSSS is higher and higher among different stage in the patients with DKD. There are significant differences among groups by Rank sum test.3. Clinical index (eGFR, BP,24hUpro, Scr, D-Dimer, PTGER2mRNA expression) of Group C patients significantly better than Group D(p<0.01)..If the patients with DKD are divided into two groups by Median of BSSS, group C of45cases is under20and group D of another55cases is more than or equal to20, there is significant difference of Scr, eGFR,24hUpro and mRNA expression of PTGER2between the two groups.4. DKD patients use PGE1treatment, efficacy significant (p<0.01). Patients of Group Control after treatment the index improvement was not statistically significant (p>0.05). The effects of PGE1to the patients with BSS in the DKD are listed as follows. The BSS, MAP,24hUpro, D-Dimer descend significantly, as the eGFR and mRNA expression of PTGER2rise significantly after treatment. The changes have no in the control group.Conclusions:1. The degree of blood stasis syndrome in diabetes patients is significantly higher than normal level crowd. Blood stasis syndrome is closely related with DM and DKD.2. DKD patient’s condition associated with Blood stasis syndrome. As the disease progresses and increase blood stasis syndrome score. The degree of BSS is significantly related to the stage of DKD. Its score ascends with the stage of DKD develops from1to4.3. Blood stasis syndrome level and diabetes clinical index relevant.(see above)4. PGE1treatment for diabetic nephropathy curative effect is distinct.(see above)...