To Investigate Ankylosing Spondylitis Early Clinical Features,Early Diagnosis,Treatment And Prognosis

Ankylosing spondylitis is a form of unkown aetiology and systemic disease characterised by chronic inflammation of axial skeletal ankylosis. It generally strikes young People in their teens, which is normally related to family history. The main pathological characteristics shows that almost all AS patients bear sacroiliitis. Accordingly it causes axial spine including sacroiliitis and surrounding tissues erosive inflammation, resulting in extensive fibrous cartilage and being ossified. The inflammation is mainly found in the synovium of axial joint, joint capsule, tendon and ligaments attach to the bone. At the later stage of disease, it develops to ankylosis, severe kyphosis deformation, being difficult to stoop and sacroiliac joint sclerosis or necrosis etc. The treatment of AS is very hard and the status of this disease is extremely difficult to control and irreversible, which leads to patient lose confidence in it. The diagnosis is not difficult when the spine becomes" bamboo spine", however, the status of the disease has reached the later stage. An early treatment is able to prevent further progression of the disease, to reduce or avoid the rate of deformity and improve the quality of patient’s life.It is very important for early diagnosis and treatment to AS.Objective:To investigate ankylosing spondylitis (ankylosing spondylitis, AS) early clinical features, early diagnosis, treatment and prognosis.Methods:We had analyzed198cases of AS early clinical manifestations, laboratory test and physical examination and imaging data, and combined with follow-up to investigate the AS clinical features of early diagnostic criteria, treatment and prognosis.Results:198cases of AS patients, the neck, the back and the ministry of pain in140cases, accounting for70.71%, peripheral joint pain in16cases, accounting for8.08%, oral ulcers, accounting for1.52%, iritis8cases of accounting for4.04percent, enough to two cases with the pain, accounting for1.01%,10cases of intestinal symptoms and systemic symptoms, accounting for5.05%, and the other19cases, accounting for9.60%. Sacroiliac joint MRI was134cases, accounting for67.68%, mainly bilateral sacroiliac joint bone marrow edema and cartilage destruction, unilateral sacroiliac joint was rare. HLA-B27positive was183cases, accounting for92.42%. ESR positive was160cases, accounting for80.81%. C-reactive protein was141cases, accounting for71.21%. Rheumatoid factor was positive in4cases, accounting for2.02%.Patients were followed up21cases, follow-up rate of10.61%, obvious symptom control was18cases, accounting for85.71%, including3patients, the symptoms disappeared completely in2patients no significant improvement, accounting for9.52%. But the basic quiescent condition was not serious direction, one cases of disease severity in patients with more serious, the lumbar vertebrae had all fusion, partial fusion of the thoracic vertebrae, the patient was misdiagnosed cases later diagnosed with the disease had been more serious, accounting for4.76%.Conclusion:In summary, the clinical features of AS for the early onset occult, and more to the neck, lower back pain and peripheral joint onset, especially in the lower limb joints, followed by the onset of tendon inflammation or heel pain, often accompanied by There were extra-articular symptoms such as fever. Had HLA-B27positive laboratory tests, CRP and ESR increased change, but early imaging changes was not obvious, and no specific diagnostic gold standard, easily misdiagnosed. Therefore stressed:All the low back was pain, especially peripheral joint pain, tendon attachment points of pain, onset of hip pain in patients, especially young people around the age of20, both men and women were asked in detail about the family history, early detection of the HLA-B27do sacroiliac joint CT, MRI, dynamic inspection and physical examination in order to strive for early diagnosis, Patients diagnosed with early use of biological agents to treatment, and symptomatic treatment, in order to improve the prognosis. Screening, negative signs should have been confirmed in patients with AS a relatives must be followed up on a regular basis to do AS-related check, for early detection of the AS, and earlier treatment.