Vascular Endothelial Growth Factor Gene Polymorphism And Endometriosis Risk: A Meta-analysis

Background: The vascular endothelial growth factor (VEGF) genepolymorphism has been reported to be associated with endometriosis risk. Thepurpose of the present study was to perform a comprehensive meta-analysis toexplore whether VEGF gene polymorphisms confer risk to endometriosis.Methods:“Vascular endothelial growth factor”、“Genepolymorphisms”、“Endometriosis” were used as keywords to searchliterature in English database including MEDLINE、EMBASE and Chinesedatabase including CBM and Wanfang et al by two evaluators respectively.Evaluated the quality of the literatures, selected and extracted material of relatedcase control studies.The STATA11.0was used for meta-analysis. Mainoutcome measures included the calculation of odds ratio (OR) and95%confidence interval (CI) of VEGF gene polymorphism between cases andcontrols.Result: An association of VEGF gene+936TC polymorphism withendometriosis was found (TC vs. CC OR=1.187,95%CI:1.024-1.375,P=0.023, heterogeneity:I2=2.8%; TC+TT vs. CC OR=1.184,95%CI:1.027-1.366, P=0.020, heterogeneity: I2=26.6%). No association between VEGF gene polymorphism-460CT,+405CG,-2578AC,-1154GA and endometriosis.Conclusion: Our results indicate that VEGF+936TC genepolymorphism is a risk factor for endometriosis, but not-460CT,+405CG,-2578AC,-1154GA.