| Objective: To investigate the expression of YB-1and P53in patients with colorectalcarcinoma of different stages and their correlation with clinicopathological features ofcolorectal carcinoma (CRC). Methods: Expressions of YB-1and P53protein in normalcolorectal mucous membrane (NCM, n＝20), colorectal low-grade intraepithelialneoplasia (LGIN, n＝30), colorectal high-grade intraepithelial neoplasia (HGIN, n＝30),colorectal carcinoma (CRC, n＝50) were detected by immunohistochemistry. Results:The strong-positive rate of YB-1expression in NCM, LGIN, HGIN, and CRC tissueswere0%,76.7%,80.0%and80.0%respectively. There were significant differences in thestrong-positive rate of Yb-1in LGIN, HGIN as well as CRC and NCM (P＜0.05). And inCRC tissue, the strong-positive expression of YB-1was statistically correlated with thelymph node metastasis and TNM staging (P＞0.05). The positive rates of P53were0%,6.7%,40.0%and60.0%respectively in NCM, LGIN, HGIN and CRC tissues. Therewere significant differences in the positive rate of P53in HGIN as well as CRC andNCM as well as LGIN (P＜0.05). The positive expression of P53was statisticallycorrelated with the degrees of tumor differentiation, lymph node metastasis and TNMstaging (P＜0.05). The expression of YB-1was positively correlated with the expressionof P53(r=0.306, P＜0.05). Conclusion: YB-1and P53play an important role in thedevelopment and metastasis of colorectal carcinoma. Combined detection of YB-1andp53protein for judging the severity and prognosis of colorectal cancer to provideimportant reference. |
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