Experimental And Clinical Research On Embedding Thread At Fenglong Point With Hyperlipidemia

ObjectiveHyperlipidemia (HLP, Hyperlipidemia) in the category of traditional Chinese medicine" blood stasis"," phlegm" category, clinical refers to the human body fat metabolism, its performance for human blood triglyceride (TG), high density lipoprotein cholesterol (HDL-C), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (apo-A), lipoprotein (PLA) and apolipoprotein B (apo-B) anomaly. These lipid markers is leading to atherosclerosis in the primary risk factors, are also associated with cerebrovascular disease and coronary heart disease incidence has very direct contact. In recent years, with the changes in people’s diet and living level, more and more people appear abnormal blood lipids, and age of onset of gradually toward the young, moreover because the hyperlipemia symptoms of occult, or most without clinical symptoms, causes people’s carelessness, missed the best time for treatment, leading to severe consequences. The current study on hyperlipidemia, clinically most of our main take orally medicine (statins, fibrates) to treat hyperlipidemia, and oral administration of Western medicine have significant side effects, especially in liver and kidney damage, and after medication discontinuation of lipids is easy to pick up, therefore, a lot of research dedicated to finding the side effects of lipid-lowering therapy, some studies suggest, Feng long hole can effectively regulate blood lipids in patients with abnormal blood lipid level. This issue through an experimental and clinical study of electroacupuncture regulating lipid for hyperlipidemia patients with arteriosclerotic effects. This topic based on the previous research, through the experimental and clinical studies to explore two aspects of Feng long point catgut embedding for hyperlipidemia lipid regulating mechanism.Methods1. Clinical study:total observation treatment of62cases of Wuhan City, is the combination of traditional Chinese and Western medicine hospital acupuncture outpatients, inpatients in Department of Cardiology and Department of acupuncture and moxibustion in hospitalized patients, are consistent with hyperlipidemia diagnostic criteria, and randomly divided into burying Fung Lung Group (30cases) and control group (30cases) of drug. The embedding Fung Lung Group, the male18, female12, mean age (53.74+9.3), disease duration2-7; drug control group,14cases of male, female16, mean age (56.91+10.2),2-11years course. Data statistics processing, embedding Feng long combination drugs, patients in the control group had no significant difference, comparable (P>0.05).2. Animal experiment:60SPF levels in male SD rats, by random principle average were divided into normal group, model group, embedding Fung Lung Group, model group and control group. Normal rats experimental full gives ordinary feed, molding, embedding Fung Lung Group, model group, model group and control group, each group were fed high fat diet. Molding time for a month, a month after the model group and the model control group continued to give high fat feeding, other groups with common feed. Catgut embedding Fung Lung Group and the model control group using catgut embedding Fung lung acupoint treatment, rat lung acupoint catgut embedding for treatment of bilateral Fung, treated once a week, a total of four, while other groups without any treatment. Long point catgut embedding abundance were observed before and after treatment for hyperlipidemia rats blood lipid indexes, as well as for rat liver structure and rat liver protein effectConelus ionClinical research:In hyperlipidemia and is not accompanied by other serious internal diseases patients, acupuncture can obviously, stability in reducing blood cholesterol and triglyceride levels; in hyperlipidemia with such as coronary heart disease, diabetes, fatty liver disease patients, electroacupuncture therapy still can reduce blood lipids, especially for low density lipoprotein regulation of atherosclerotic plaque formation is more significant, for preventing and curing effect.Animal experiment:lin hyperlipidemic rats the regulation of blood lipid 30days after treatment, the rats in the model group compared with normal group, LDL-C plasma TC increased significantly (P<0.01), while TG and HDL-C did not change significantly (P>0.05); control rats plasma TC, LDL-C compared with the model group was significantly decreased (P<0.01), compared with the normal group increased significantly (P<0.01); model control group and high model group, TC and LDL-C significantly decreased (P<0.01), embedding group in rat plasma TC, LDL-C compared with the control group, significantly reduced (P<0.01), plasma levels of TG and HDL-C did not change significantly (P>0.05). Description of long hole can downregulate the embedding abundance of blood lipid in rats with hyperlipemia in TC, LDL-C levels, there was statistical significance.2for hyperlipidemia rat liver morphological changes ofCompared with the model group, hepatic tissue embedding group contained within the lipid droplet number decreased significantly; compared with the control group, liver tissue embedding group containing lipid droplets also has the obvious decline.3for hyperlipidemic rats, ABCA1, LXR, RXR alpha expression and content.Catgut embedding therapy group and control group with model to promote the liver LXR activation and RXR-a combination so as to effectively induces ABCA1expression in the role of.