| Purpose:Chronic viral hepatitis c is a great harm of infectious diseases, At present the main treatment drug is interferon, but because the interferon in the clinical application of restricted by all kinds of factors, so for traditional Chinese medicine drug treatment of slow the effect and safety of hepatitis c is necessary. This topic through the contrast with interferon, observation traditional Chinese medicine protect liver and recovery function pill joint interferon treatment of chronic hepatitis C clinical curative effect, through the syndromes product points, liver function, liver fiber four, HCV-RNA, routine blood, kidney function, electrocardiogram, the change of the index, And this drug component characteristics, this paper discusses the treatment of hepatitis c the advantages and shortcomings, is slow and provided the hepatitis C more widely thought.Methods:1. The experimental method:Random will all qualified participants were divided into two groups:treatment group and control group all32cases, a total of 64patients.by tried in wuhan, hubei province are from the GanDanKe hospital outpatient department and the inpatient department in June2010to August2011clinic of patients, which conform to the test diagnosis standard.2. Experimental method:The control group gives ordinary interferon plus ribavirin therapy, ordinary interferon,5million u/time, separate Th subcutaneous injection or muscle, and oral ribavirin1000mg/day, The treatment group and control group in the basis of use protect liver after work pill treatment, three times daily oral, every time6g. Test the treatment:24weeks.3. Observation index:Therapeutic indexes:the clinical symptoms, liver function points (ALT, AST, TBIL, ALB), liver fiber four, HCV-RNA. Safety index:routine blood, kidney function, thyroid function, ecg examination.4. Statistical analysis:After the end of experiment, all the test data using the spss13.0statistical software to analysis. All measurement data are to s said, significant test using t-test, and counting material adopt U inspection and x2inspection. P<0.05will be considered by the testing difference with a statistical significance.Results:1. The total curative effect is:treatment group32cases,11cases were markedly improved, effective18cases effectiveness and3cases, the total effective rate of90.62%;30cases in,8cases were markedly improved, effective in13,9cases failed, with the total effective rate was70.00%, the Ridit inspection, P<0.05, explain the comprehensive effect of the treatment group than in control group.2. Effect of TCM symptoms comparison:treatment group and control group total effectiveness93.75%and66.67%, respectively, The chi-square test, two groups of patients after treatment is the total effective rate, significant difference (P<0.01), treatment Group was better than control effect of TCM symptoms.3. Liver function curative effect comparison:two groups of patients after treatment were significantly down ALT, AST, the t test, all significant difference (P<0.01), between the two groups after treatment with significant difference (P<0.01); Two groups after treatment were statistically significant TBIL down (P<0.05), including the treatment group down more obvious (P<0.01), between the two groups after treatment with significant difference (P<0.05); Two groups of ALB changes before and after treatment was not statistically significant (P>0.05). Explain the treatment group and protect liver after work with a control group shot has obviously improved the action of liver function.4. Liver fiber index curative effect is:treatment group after treatment, the index of liver fibrosis declined obviously, the t test, all significant difference (P<0.05), which HA and LN improved significantly (P<0.01), and the control group HA, LN drop significant difference (P<0.05); After treatment, the comparison between the two groups are significant difference (P<0.05), which HA improve the most obvious (P<0.01). That protect liver after work shot in the prevention and control of liver fibrosis has obvious advantages, especially the decline of HA.5. HCV-RNA comparison:treatment group HCV-RNA turn Yin rate is higher than the control group, but both comparison, no significant Sexual difference (P>0.05), indicating that protect liver after work pill joint interferon therapy of hepatitis c virus in without obvious Advantage.6. Safety observation:patients adverse reaction was higher than the proportion of the treatment group by statistics Learn analysis, the control group influenza-like syndrome and reduce the incidence of white blood cells is the treatment group significant difference (P<0.05). That protect liver after work shot in the reduce interferon and ribavirin in side effects have certain effect.Conclusion:Research shows that, interferon plus ribavirin combined with the foundation of the liver after work for the treatment of chronic illness c pills Viral hepatitis, can obviously improve the syndromes, improve liver function index, especially of liver fiber aspect have the obvious The advantage of clinical use safety and no side effect, can reduce the incidence of aderse eents interferon, is worth pushing Wide use. |
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