Research On Risk Factors Of Cerebral Infarction And Vascular Endothelial Function And Mechanism Of Salvianolate Protected Endothelial Function In Patients With Acute Cerebral Infarction

[Objective]Explore the relevance of the risk factors for cerebral infarction and flow-mediated dilatation and the mechanism of salvianolate protected endothelial function in patients with acute cerebral infarction.[Methods](1) The part of study risk factors of cerebral infarction and vascular endothelial function:Selected flow-mediated dilatation (FMD), von willebrand factor (vWF) and soluble endothelial protein C receptor (sEPCR) as the evaluation index which evaluate endothelial function in patients with cerebral infarction. Divided the patients with acute cerebral infarction into multiple risk factors group, single risk factors group and control group.All patients underwent brachial artery endothelial function testing.detected the plasma vWF and sEPCR levels by ELISA. Groups were compared using independent samples t test.And using multiple linear regression analysis, that regarding FMD, vWF and sEPCR as the dependent variable, and hypertension, diabetes, hyperlipidemia as independent variables.(2) The part of mechanism of salvianolate protected endothelial function in patients with acute cerebral infarction:Selected vWF and sEPCR as the evaluation index which evaluate endothelial function in patients with cerebral infarction. Selected36patients with acute cerebral infarction, and divided the patients with acute cerebral infarction into Conventional therapy group and salvianolate treatment group. Selected20healthy people as control group. Tested the vWF and sEPCR plasma in levels before and after the treatment.[Results](1) The part of study risk factors of cerebral infarction and vascular endothelial function:vWF and sEPCR plasma in levels and FMD of multiple risk factors group and single risk factors group were significantly lower than the control group (p<0.001).FMD of cerebral infarction group was significantly lower than the control group(p<0.001).The plasma vWF and sEPCR levels in multiple risk factors group were significantly higher than single risk factors group(p<0.001). The change of FMD is closely related to hypertension (standardized partial regression coefficient-0.510, p<0.001), followed by diabetes (standardized partial regression coefficient is-0.344, p<0.003). The change of vWF is the most closely related to diabetes (standardized partial regression coefficient is0.589, p<0.001), followed by hypertension (standardized partial regression coefficient is0.374, p<0.001). The impact of hypertension on the content of sEPCR significant risk factors compared with other cerebral infarction (standardized partial regression coefficient is0.571, p<0.001), followed by-diabetes (standardized partial regression coefficient0.344, p <0.001).(2) The part of mechanism of salvianolate protected endothelial function in patients with acute cerebral infarction:The plasma vWF and sEPCR levels in patients with acute cerebral infarction were significantly higher than control group(P<0.0001). The difference of the plasma vWF level before and after treatment was significantly lower than conventional treatment group(P=0.005). And the difference of the plasma sEPCR level before and after treatment was not significantly different than conventional treatment group (P>0.05).[Conelusion]The more risk factors for cerebral infarction, vascular endothelial dysfunction is more severe. Salvianolate has a protective effection on endothelial function by reducing the plasma vWF level of patients with acute cerebral infarction.