The Expression Of LOXL1and TGF-β1in Adenomyosis And Its Clinical Significances

objective:To explore the role of lysyloxidase-like1(LOXL1) and transforming growth factor-β1(TGF-β1) in the pathogenesis of adenomyosis and clinical significances.Methods:The expression of LOXL1and TGF-β1in the ectopic and eutopie endometrium of30cases with adenomyosis (ectopic endometrium group and eutopic endometrium group) and in the normal endometrium (control group) of20cases without endometriosis were detected by the immuno-histochemical method.Results:The average optical density of LOXL1in ectopic endometrium, eutopic endometrium and normal endometriun were0.22±0.10,0.15±0.09and0.15±0.06).The expression of LOXL1in ectopic endometrium group was significantly higher than eutopie endometrium group and control group(P<O.05).The average optical density of TGF-β1in ectopic endometrium,eutopic endometrium and normal endometriun were0.26±0.02,0.16±0.03and0.15±0.02.The expression of TGF-β1in ectopic endometrium group was significantly higher than eutopie endometrium group and control group (P<O.05). There were positive correlation between the expressions of LOXL1and TGF-β1in ectopie endometrium group and eutopic endo-metrium group (r=0.402,P<0.05). There were not correlation between the expressions of LOXL1and TGF-β1in eutopie endometrium group (r=0.24,P>0.05). There were not correlation between the expressions of LOXL1and TGF-β1in normal endometriun group (r=0.20,P>0.05).The expression of LOXL1in ectopic endometriun were related with the size of uterus and adenomyoma (P<0.05). The expression of TGF-β1in ectopic endometriun were not related with uterus size, adenoma-yoma, dysmenorrhea and menorrhagia (P>0.05).Conclusion:1.The abnormal expression of LOXL1and TGF-β1in ectopic endometrium of patients with adenomyosis may be associated with the pathogenesis and progression of adenomyosis.2.The expression of LOXL1in ectopic endometrium of patients with adenomyosis were related with the size of uterus and adenomyoma.