Epidemiological Investigation Of Asthma And Analysis Of Its Determinants In Children Aged0～14Years In Changsha City

Objective:An epidemiological study was conducted to explore the prevalence and determinants of childhood asthma in the children aged0-14years in changsha city, and provide the basis for sustained asthma prevention and control efforts for children.Methed:①With stratified random sampling method,13929children at age of0-14years (children was born at0:00on July1st,1996～at11:59on June31st,2010) in Furong district of changsha city were surveyed with a screening questionnaire’asthma and allergic disease screen’. Questionnaires answered by parents, not less than90%replied, then inputs the screening information into electronic version.②From the Screening form,who answer’YES’to any items of1～6",would be diagnosed asthma or non-asthma by experts. Children diagnosed asthma should answer the sheet’questionnaire for asthmatic children aged0-14’.③At the same time,we selected271nonasthmatic healthy children as controls, who have close constitution of age, gender and race with controls, and answer the sheet’questionnaire for nonasthmatic children aged0-14’.④Statistical Methods:input the questionnaires by Epi-info software, SPSS software was used in the statistical analysis of results.Results:①A total of13,929children surveyed, and there are12,719children finished the questionnaire. The response rate for the questionnaire was91.31%. There were482cases screened out from the12719subjects as asthma associated children. Among them there were353children diagnosed as asthma (including infantile asthma),48as cough variant asthma,81as suspicious asthma(including asthma bronchitis); the childhood asthma prevalence rate was 3.79%.Children aged1-2and6-7had the highest prevalence,6.28%and6.26%respectively,.②the male/female ratio of prevalence is1.59:1; The statistical difference was significant (P<0.05).③The average age of onset was2.36yrs.30.1%asthmatic children had their onset before1yrs.70.7%had before3yrs.just6.2%had their onset after6yrs.④The main triggers of childhood asthma were respiratory tract infections (87.3%)、changes of weather/cold air (57.1%)、all kinds of irritating odor (56.1%)、food (16.6%)、 exercise (13.2%),etc⑤Case-control study logistic regression showed,family history of asthma or allergy (OR=3.174),personal history of allergic rithinitis (OR=2.312),drug allergy (OR=2.980),food allergy (OR=2.391),skin allergy (OR=2.693),antibiotic us (OR=2.602),born by C-section (OR=1.631), fireproofing furniture (OR=2.051),wallpaper(OR=0.382),these9factors enter the regression model,P<0.05.Conclution:1.The prevalence of childhood asthma in changsha city was3.79%.2.The occurrence of childhood asthma was related to many factors. Family history of asthma or allergy, personal history of allergic rithinitis, drug allergy, food allergy, skin allergy, antibiotic use, born by C-section, fireproofing furniture maybe the risk factors.