FuFanghuaimi Decoction Treatment Of Children Due To Blood-heat Psoriasis Vulgaris Clinical Observation And Mechanism Study

Objective：To observe the clinical efficacy of FuFanghuaimi decoction in treatment ofchildren with psoriasis vulgaris due to blood-heat and to investigate the possiblemechanisms in the pathogenesis of PV. Methods：60cases of children with an unusual typeof blood-heat type psoriasis patients were randomly divided into two groups,treatmentgroup(the group of FuFanghuaimi decoction)and control group(the group of XiaoYingrain),the course of treatment was8weeks.Before and after the treatment, to observe twogroups of patients’ the lesion area,the skin’s color,the degree of hypertrophicscaling,infiltration rate,itching condition etc the change of signs and the adversereaction.Evaluation of its curative effect by the scores of PASI before and after thetreatment. Measure the level of serum TNF-α and IL-6before and after the treatment.Results：The clinical cure and obvious rate was73.33%，the effective rate was93.33%，the control group were46.67%and80.00%. As to the recrudescent rate and theside-effective rate，there were significant differences between the two groups. The level ofserum TNF-α and IL-6decreased obviously after the treatment. Conclusions：The clinicalefficacy of FuFanghuaimi decoction for children with psoriasis vulgaris due to blood-heatis effective and the adverse reaction was less. The possible mechanisms of its action mightbe to clear heat and cool blood detoxification,improve microcirculation,regulate theimmune,resist the inflammatory response.