Relationship Between Serum γ-glutamyltransferase And Metabolic Syndrome Components In Patients With Hypertension

Objective： To explore the relationship between serum γ-glutamyltransferase (GGT) andmetabolic syndrome (International Diabetes Federation in2005published diagnostic criteriafor metabolic syndrome worldwide,” China targets” as the standard diagnosis) and itscomponents in patients with hypertension in Lianyungang rural communities. Gamma-glutamyltransferase was analyzed for metabolic syndrome, to provide a more scientific basisfor prevention and diagnosis of the metabolic syndrome in hypertensive population.Methods： Subjects with hypertension aged45-75years and living in Lianyungang ruralcommunities were recruited. Data were collected by the questionnaire, blood pressuremeasurement and physical examination. Serum samples were collected to detect bloodglucose, glutamyltransferase and lipid. T-test, chi-square test, logistic regression，multipleregression were used to analyze the related indexes.Results: A total of12726individuals that included4665men and8061womenparticipated in the survey. GGT level of total population is23.0(17.0,34.1) U/L (men:29.0(21.0,46.0)U/L; women:20.0(15.0,28.8)). GGT levels (GGT≥50U/L) accounted for11.1%(men:21.7%; women:5.0%)，The prevalence of MS(IDF) in total population is41.2%(men:24.0%,women:51.4%). The presence of MS, its components, and the number ofmetabolic abnormalities (except for HDL-C) increased with GGT level in both gender. Theadjusted ORs and95%CIs were calculated by logistic regression analysis to determine therisk of elevated GGT according to the number of components of the metabolic syndromeafter adjusting for age, smoking, alcohol drinking, education, economic level and so on. The odds ratios of abdominal of obesity for elevated GGT in men were3.18(95%CI:2.62,3.87),in women were2.46(95%CI:2.11,2.86). The odds ratios of high fasting blood glucose forelevated GGT in men were3.59(95%CI:2.99,4.30), in women were3.59(95%C:3.12,4.14)with; The odds ratios of high triacylglycerol concentrations in men5.97(95%CI:5.97,9.95)and in women7.38(95%CI(6.15,8.86); The odds ratios low HDL-cholesterol concentratein men were0.43(95%CI:0.30,0.62), in women were0.94(95%CI:0.80,1.10); The oddsratios of low metabolic syndrome for elevated GGT in men were5.30(95%CI:4.19,6.70)andin women were3.63(95%CI:3.16,4.17).Multiple regression analysis showed that GGTlevels is closely related to FPG (man: β=0.3052, P <0.001, woman: β=0.4350, P <0.001),and total cholestrol (man: β=0.3716,P <0.001, woman: β=0.2449, P <0.001)Conclusion: GGT is positively correlated with triglycerides, fasting blood glucose andmetabolic syndrome in patients with primary hypertension. With the elevated GGT levels,the MS risk gradually increased. GGT as an early prediction biochemical indicator ofmetabolic syndrome has a wide range of value.