The Advantages Of Research After Laparoscopic-assisted Radical Resection For Rectal Cancer On The Recovery Of The Body Function In The Patients

Object:The safety and short-term benefits of laparoscopic rectal cancer reaection remain debatable. The rectal (rectal cancer Laparoscopic or Open Resection) trial was done to assess the safety and benefit of laparoscopic resection compared with open resection for curative treatment of patients with cancer of rectal.Surgical trauma suppresses host immune function, potentially creating an environment vulnerable to tumor cell growth. This study compared immune function after laparoscopy with conventional rectal tumor resections.Materials and Medthods:From June2010to December2011,60patients with rectal cancer received radical resection of the rectum;30of them received laparoscopic surgery and the other30received open resection.The peripheral blood was collected from the patients before the operation, and one and three days after the operation to detect the levels of IL-6、 IL-8、TNF-α、IgA、IgG、IgM and CRP. In addition, data collected included the following:age, sex, body mass index, surgical time, blood loss, length of incision, time to ambulation, time to bowel function, length of stay, and complications.Results:Of the received laparoscopic surgery group of30patients studied,13were men and17were women. Their mean age was53.1years(53.1±12.1). The mean body mass index was20.5kg/m2(20.5±2.0).The mean duration of surgery was192minutes(192.0±19.2min) and the mean surgical blood loss was116ml(116.0±47.0ml). The mean length for incisions was6.9centimeters (6.9±0.4cm).The mean time to ambulation was1.2days(1.2±0.2d).The mean time for flatus was2.9days(2.9±0.4d).This corresponds to a mean hospital stay of8.7days(8.7±0.8d). Complications occurred in only2patients:1anastomotic leak and1superficial surgical site infection. The received conventional surgery group of30patients studied too,15were men and15were women. Their mean age was54.2years(54.2±14.9). The mean body mass index was20.8kg/m2(20.8±2.3).The mean duration of surgery was159minutes(159.0±16.0min) and the mean surgical blood loss was230ml(230.0±117.0ml). The mean length for incisions was16.7centimeters (16.7±1.0cm). The mean time to ambulation was1.8days(1.8±0.4d).The mean time for flatus was3.7days(3.7±0.6d).This corresponds to a mean hospital stay of11.7days(11.7±2.1d).Complications occurred in3patients:1superficial surgical site infection and2pulmonary infection.Serum levels of IL-8、IgA、IgG and IgM showed no significant changes before and after operation in both groups.The TNF-α levels increased on the day1and day3after operation in both groups, secrum IL-6and CRP levels were significant lower after laparoscopic surgery than that of the conventional procedure.Conclusion:The results of ongoing clinical trials are still needed to further evaluate the role of laparoscopic assisted rectal resection in patients with potentially curable rectal cancer. However, the results of my trials prove that laparoscopic-assisted radical resection for rectal cancer brings up a less depression to immune system and a quicker recovery.