Clinical Analysis Of Hemagglutination Index In634Patients With Malignant Tumor

ObjectiveTo investigate the coagulation disorder in patients with malignant tumor, and analyse related factors,clinical significance.Material and MethodsThe index (PT, APTT, TT, Fib, D-dimer, PLT) of634hospitalized patients with malignant tumor and243patients as control in Provincial Hospital Affiliated to Shandong University from January1,2010to October31,2010were collected. Statistical data were analysed by software SPSS13.0for Windows. Large sample U test was used to compare the index. P<0.05was considered as statistically significant, while P<0.01was considered as dramatically statistically significant.Results1.General condition of the sampleAmong the634patients with malignant tumor, there are334men cases and300women ones; age ranges from15to91years old, and56years old for average; different types of tumor are as follows:lung cancer103cases, breast cancer89cases, colon-rectal cancer73cases, esophageal cancer70cases, gastric cancer66cases, liver and biliary cancer61cases, nephritic cancer25cases, thyroid cancer22cases, cervical cancer18cases, pancreatic cancer17cases, lymphoma17cases, bladder cancer12cases, ovarian cancer10cases, laryngeal cancer10cases, retroperitoneal cancer9cases, brain cancer9cases, the primary site unknown cancer9cases, prostate cancer7cases, nasopharyngeal cancer4cases, scrotal cancer2cases, leukemia1eases. Among the243patients as control, there are126men cases and117women ones; age ranges from16to89years old, and55years old for average. They are all non-tumor patients who receive residential treatment in ophthalmology department of Provincial Hospital Affiliated to Shandong University from June1,2010to December31,2010.The two groups can match for the general demographic characteristics.2.Comparison of abnormal cases and rate between malignant tumor and control groupThere are337abnormal cases in malignant tumor group, abnormal rate is53.2%, while there are48abnormal cases in control group, abnormal rate is19.8%. The difference is statistically significant (P<0.01).3.Comparison of hemagglutination index between malignant tumor and control groupPT, APTT, Fib and D-dimer are significantly higher in tumor patients(P<0.01); While TT, PLT does not change markedly (P>0.05).4.Comparison of hemagglutination index between initial and comprehensive treatment groupPT, APTT and D-dimer are significantly higher in comprehensive treatment patients(P<0.01); While TT, Fib, PLT does not change markedly (P>0.05).5.Comparison of hemagglutination index among different types of tumorFib varies largely in different types of tumor. There are statistical differences of Fib in lung cancer and esophageal cancer patients(P<0.01); PT, PLT and D-dimer are higher in all the types (P<0.05); APTT is higher while TT is lower in most types (P<0.05).ConclusionCoagulation disorder definitely exists in the patients with malignant tumor. The rising of PT, APTT, D-dimer in tumor patients is a risk factor that lead to thrombotic disease, which should be properly monitored in order to decrease the happen of correlated complications. The disorder may has a relationship with tumor itself, treatment process and tumor types. But the specific interaction among them has not been decided yet. That is what we should research next.