The Clinical Research On Radioactive Secretory Otitis Media Intervened And Traeted By LongDan XieGan Pill

ObjectiveIn this project, LongDan XieGan pill or placebo were given to take by all thepatients with NPC who received radiotherapy and the tests of electric auriscope、pure-tone audiometry、acoustic dynamic immittance、eustachian tube function wereperformed and the subjective symptom were evaluated and the curative effect of drugswere evaluated in different time periods during and after the radiotherapy. In addition,all the related data which came from different periods such as the period before theradiotherapy with a radiotherapy dosage of20Gy,30Gy and50Gy respectively, theend of the radiotherapy, three months after the end of the radiotherapy and six monthsafter the end of the radiotherapy was analyzed,and dynamically observes theincidence of the radioactive secretory otitis media（RSOM） and the integral value ofmiddle ear of NPC patients during the whole observation period. The regularity ofoutbreak of RSOM and the variation rule of the integral value of middle ear wereresearched,from which a conclusion that the effect of LongDan XieGan pill intervenesRSOM and integral value of middle ear can be drawn. Further,the RSOM diagnosedwhich came from before the radiotherapy till six months after the end of theradiotherapy was put on the phase of drug treatment,the effect of Clinical control thatLongDan XieGan pill treated the RSOM in six months after the end of theradiotherapy was analyzed,from which a conclusion that the effect of RSOM treatedby LongDan XieGan pill can be drawn.MethodsSelect120NPC patients with radiotherapy who met the standard randomly anddivided them into groups to have a comparison.Experimental group included90patients receiving the radiotherapy：The first group with30patients: at the beginning of radiotherapy, these patients should have a placebo，till doses up to20Gy to six months after the end of theradiotherapy, these patients should have drugs to do intervention and prevention.The second group with30patients：at the beginning of radiotherapy, these patientsshould have a placebo, till doses up to30Gy to six months after the end of theradiotherapy, these patients should have drugs to dointervention and prevention.The third group with30patients: at the beginning of radiotherapy, these patientsshould have a placebo, till doses up to50Gy to six months after the end of theradiotherapy, these patients should have drugs to do intervention and prevention.Control group included30patients receiving the radiotherapy, from the beginningto the end of the radiotherapy have the placebo to do intervention and prevention.Results1.The earliest time of the RSOM appearing in every group was when the radiationdose reached to30Gy,the most frequent time of the RSOM appearing was that threemonths after the end of the radiotherapy and six months after the end of theradiotherapy,and the RSOM appearing will not end with the end of the radiotherapy.2.With the radiotherapy going on, the integral value of middle ear of these NPCpatients was inclined to decrease during the whole observation period.This projectfound that the integral value of middle ear in the two periods(from the beginning ofthe radiotherapy to the doses reached to20Gy and from the doses reached to30Gy tothe three months after the radiotherapy) was inclined to decrease evidently. Theintegral value of the end of experimental group was inclined to increase gradually atthe three months after the end of radiotherapy, while the control group decreased allthe tine during the whole observation period.3.Through the X2test，there was significant difference on the curative effect ofthe RSOM intervening and preventing between the experimental group and thecontrol group(p<0.05).Through the Mann-Whitney U test, there was significantdifference on the integral value of the NPC patients intervening between theexperimental group and the control group. Conclusions1.The earliest time of the RSOM appearing in every group was when the dosereaches to30Gy,the most frequent time of the RSOM appearing was at three monthsafter the end of the radiotherapy and six months after the end of the radiotherapy.If anearly intervention was done, the incidence of the RSOM could be reduced, thefunction of middle ear of NPC patients and the life quality of the NPC patients wasimproved.2. Longdan Xiegan pill could evidently decrease the incidence of the RSOM ofthe NPC patients during the whole observation period, and the clinical control ratewas higher significantly the control group.3. The integral value of middle ear in the two periods(from the beginning of theradiotherapy to the doses reached to20Gy and from the doses reached to30Gy to thethree months after the radiotherapy)were inclined to decrease evidently. The integralvalue of middle ear was intervened and the function of middle ear was improvingobviously during the whole observation period.