Clinical Analysis Of86Young Breast Cancer Cases

Objection: To investigate clinicopathological features and prognosis ofyoung breast cancer in the southwest of China.Material and Methods: We analysed the data on1478breast cancerfemale patients who were treated in the Second Affiliated Hospital ofChongqing Medical University and Cancer Hospital of Chongqing betweenJanuary2009and December2011. A total of113(7.6%) were younger than35years of age.There were86operable patients whose case histories wererelatively integrated, including pathological report, immunohistochemicalreport and systemic therapy records. All86patients underwent breastsurgery, of which10cases breast conserving treatment and76casesmodified radical mastectomy.86cases of breast cancer patients wererandomly selected in the same period，who were above35years old anda11women，as control group，aged from35to78years old，medium agewas56-year-old．Retrospective analysis was done to compare the youthgroup with the control group in the pathological type，tumor size，axillarylymph node metastasis, TNM classification, estrogen and progesteronereceptors(ER，PR)，Ki-67，and C-erbB-2protein expression. All statistical analyses were carried out by using SPSS, version13.0．The Chi-square testwas used to evaluate the differences in the pathological type，tumor size，axillary lymph node metastasis, TNM classification, ER，PR，Ki-67andC-erbB-2protein expression between the pair of groups, P＜0.05considered statistically significant difference．Result: The infiltrating duct carcinoma was predominant inpathological types of young breast cancer for64.0%(55/86). There is nosignificant difference in the pathological type，tumor size，PR positive rateand expression of Ki-67protein between the young group and controlgroup. The positive rate of sentinel node in the young group wassignificantly higher than the control group(64.0%vs43.02%, χ2=7.572，P=0.006)．The difference of TNM classification between the two group wassignificant, and there were more young patients in stage Ⅲ and Ⅳ(χ2=6.908, P=0.032). The expression of estrogen receptor(ER) wassignificant lower than control group’s(44.2%vs66.3%, χ2=8.488，P=0.004)，while the positive rate of progesterone receptor(PR) was higherwithout statistical significance. There was significant difference in positiveexpression rate of C-erbB-2protein between two groups(68.6％vs40.7％,χ2=13.512，P=0.00).Conclusions: Young breast cancer has unique pathological featuresthat expression of estrogen receptor(ER) was significantly lower than thatof the older age-group while expression of C-erbB-2protein was higher. Additionally, the positive rate of sentinel node in the young group wassignificantly higher than the control group. The pathological featuresabove potentially posed young breast cancer to progress faster, transferearlier and have poor prognosis．Earlier diagnosis and regular synthetictherapy would hopefully improve the survival state and live time of youngbreast cancer patients.