Expression Of Fascin And Correlation With MVD In Sinonasal Inverted Papilloma

Objective：To investigate the expression of Fascin in sinonasal inverted papilloma(SNIP)and the relationship between Fascin expression and microvessel density(MVD).Methods：The expression of Fascin and CD34were determined by immunohistochemistryin30cases of SNIP，12cases of nasal squamous cell carcinoma(NSCC) and10casesof normal inferior turbinate(IT) tissues.Meanwhile, CD34, a measure of MVD, wascounted at the same time. All the data are analyzed by spss l3.0，P<0.05is refered tostatistically significant difference．Results：Fascin was expressed in17of30(56.6%) cases of SNIP，10of12(83.3%) casesof NSCC and2of10(20%) cases of normal IT tissues.Expression of Fascin wassignificantly increased in SNIP and NSCC compared to normal tissues(P<0.01).MVDcounts was23.64±2.74、45.10±5.45、74.76±7.32,respectively(P<0.001).There was apositive corrlation between the expressions of Fascin and MVD counts.Conclusions：The high expression of Fascin and angiogenesis are significantly associated withbiological behaviour of SNIP.Fascin may play an important role in the phathogenesisof SNIP and NSCC and synergic role with angiogenesis in progression of SNIP.