| Background and Objective:Abdominal aortic aneurysms (AAAS) are a major cause of morbidity and mortality in the western world and are one of the leading causes of death in the united Stares, where approximately45000deaths per year are attributable to AAA alone. The incidence and prevalence of AAA is increasing, a ruptured AAA has an associated overall mortality of80%. The pathogenesis of AAAs is a multifactorial degenerative vascular disorder. The prevalence of diagnosed type2diabetes in men over60-the group most at risk of developing abdominal aortic aneurysms (AAAs)-is estimated between10-15%.previous studies have identified risk factors for AAA, including advanced age,male gender,white race, smoking,taller stature, hypertension, hypercholesterolemia,obstructive airway disease, and peripheral vascular disease. as to AAA disease,our major challenge faced in clinical practice is effective drug therapies to prevent rupture of AAA.At present,there was not definite evidence that other drugs had a role in inhibiting AAA rupture except for beta blocker. The prevalence of both diabetes and AAA has risen in recent years. Abdominal aortic aneurysm (AAA) is defined as a permanent dilatation of the abdominal aorta and is the tenth leading cause of death in older men. Despite theoretical common pathogenic mechanisms, the association between AAA and diabetes remains unclear and published work in this area is limited, incomplete and often conflicting. The purpose of our study focused on evaluating the effect of diabetes mellitus on longitudinal extension in AAA progression.Materials and Methods:We studied460male and female patients with AAA, aged41to92years, at least twice admitted into our hospital from January2000to April2010. All of them accepted abdominal vascular ultrasound examination for scanning maximal length, transverse diameter and anteroposterior diameter of abdominal aortic aneurysm at each admission period. Height and weight were measured when the patient was admitted lastly into our hospital, and body mass index (BMI) was computed as weight divided by height squared (kg/m2). Age was recoded when patient was lastly admitted into hospital. Blood pressure was a mean value of their first and last admission into our hospital.Results:Our results indicated that anteroposterior diameter changes were associated with serum homocysteic acid, and transverse diameter changes were in connection with serum creatinine. CCB therapy was negatively related to AAA rupture, and possibly was another kind of drug for prevention of AAA rupture apart from beta blocker. The protective role of CCB for prevention of AAA rupture may be associated with lowering C reactive protein levels. Length changes were positive association with changes of anteroposterior and transverse diameter. Diabetes mellitus was related to length extension, but no to transverse expansion in AAA progression, and length increases of AAA were observed in patients with diabetes as compared with those without diabetes. Glycosylated hemoglobin wasn’t significant different between diabetes patients and non-diabetes patients. Bivariate correlation and partial correlation analysis indicated that diabetes mellitus was associated with length extension of AAA.Conclusions:CCB therapy is negatively related to AAA rupture,and possibly is another kind of drug for. Diabetes mellitus is related to extension of length growth of AAA and receiving better hypoglycemic treatment didn’t affect extension of aneurysm progression in diabetes patients. Transverse diameter expansion is related to elevation of serum creatinine, and possibly provokes renal dysfunction. |
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