Study On Blood UrineTGF β1and Diabetic Nephropathy Proteinuria Level And Its Card-based Correlation

[Objective] Clinical comparative study of normal healthy population, the DM patients and DN patients with blood,urinary TGFFβ1level and to explore the blood, urine TGFβ1as indicators of diabetic nephropathy Qiyinliangxu objectivity of dialectical possibility.[Methods] Collected during the period from2011to2012, the Chinese Medicine Hospital of Jiangsu Province and Jiangsu provincial authorities hospital outpatient and inpatient meet the inclusion criteria,67cases of patients with T2DM, according to the level of proteinuria is divided into three groups:30cases of patients with normal albuminuria, a small amount of protein urine in patients with23cases,14cases of massive proteinuria in patients.TCMdivided into30cases of Qi Deficiency;37cases of non-Qi Deficiency; another raise of21cases of normal healthy people. Clinical observation of indicators of glucose metabolism:fasting blood glucose (FBG), glycated hemoglobin (HbA1C); indicators of lipid metabolism:total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C). Blood, urine TGFβ1enzyme-linked immunosorbent assay (ELISA), blood, urine TGFβ1kit were purchased from Wuhan according to Kesai Biological Products Company.[Results]1.DN group Qiyinliangxu incidence was significantly higher than the DM group (P=0.012).2.DM Qi Deficiency age group, the blood of TGFβ1, the urine of TGFβ1, the urine ACR, serum creatinine were higher than Qi Deficiency group (P=0.031; P=0.008; P=0.000; P=.000; P=0.003).3.DN Qi Deficiency group of TGFβ1blood, urine of TGFβ1, the ACR in urine, serum creatinine were higher than Qi Deficiency group (P=0.008; P=0.000; P=0.000; P=0.003).4. four groups of blood TGFβ1in descending order of DN Qi Deficiency group, the DN non-Qi and Yin deficiency syndrome group, DM Qi Deficiency group, the DM non-Qi Deficiency syndrome group; urinary TGFβ1descending order for the DN Qi Deficiency group, DM Qi Deficiency group, the DN non-Qi Deficiency group, the DM non-Qi Deficiency group.5.Qi Deficiency serum TGFβ1and urine ACR5.DN was positively correlated (r=0.42, P=0.036). DN non-Qi Deficiency of serum TGFβ1, no significant correlation between urinary TGFβ1and clinical indicators.6.DM group of blood TGFβ1, although increased compared with normal healthy control group, but no statistically significant difference (P=0.303>0.05). High urinary TGFβ1had a significant difference (P=0.022).7. DN group of blood, urine of TGFβ1, urine ACR, Cr, were significantly higher than the DM group (P<0.01). DN group, serum TGFβ1and urine the ACR, Cr, urine TGFβ1was positively correlated (r=0.631, P=0.000; r=0.709, P=0.000; r=.653,P=0.000). DN group urinary TGFβ1and age of urine to the ACR, Cr were positively correlated (r=0.281, P=0.021; r=0.906, P =0.000;r=0.842,P=0.000).[Conclusions]1.the DN Qiyinliangxu incidence was significantly higher than the DM group, prompt Qiyinliangxu may be prompted to the development of the disease.2.Urine the TGFβ1value Qi Deficiency group than the non-Qi Deficiency group, derived from the statistical results Tip:urinary TGFpl and are closely related to Qi Deficiency, dialectical objectivity of one of the indicators can be used as the certificate.3.Urinary TGFβ1in DM have been significantly increased blood TGFβ1compared with the normal group, although elevated, but no significant difference. Prompted elevated urinary TGFβ1reflect kidney inflammation caused by metabolic disorders, early intervention, to prevent the occurrence of the DN.