Study On The Related Factors And Prevalence For The Parkinson’s Disease Of Uygur Residents In The Area Of Hetian,xinjiang Uygur Autonomous Region

Objective: To observe the related factors and prevalence for the Parkinson’s diseaseof Uygur residents in the area of Hetian,Xinjiang Uygur Autonomous Region.Methods:Application of cluster random sampling method, randomly selected the people aged45and above of a permanent resident (≥10years),who come from the city of Hotan, Yu-tian County, Moyu County and Lopu County at the Hetian Prefecture,Xinjiang.Whichhave jurisdiction over seven counties and one city to conduct an epidemiological survey.In accordance with international PD diagnostic criteria for screening PD patients, usingcase-control study, randomly selected not suffering from PD and other diseases of thenervous system of1:1as control group,and in the same with the case group in terms ofgender, tribes, age(±2) match. Application of structured questionnaires, survey face toface the related factors of PD.The database was established useing EpiData3.1softwarewith two independent entry,analysis the prevalence rate of each age group in Hetian, Xin-jiang, and statistical analysis was performed using SPSS19.0statistical software. Theodds ratio(OR) associated with exposure variables and PD risk were assessed by usingunivariate analysis and multivariate conditional logistic regression analysis,meanwhile,the95%confidence interval (95%CI) and P-value were also calculated. The statistical signi-ficance was P <0.05. Results: A total of5932cases of people receiving the survey inHetian Prefecture,Xinjiang,which found that88cases of PD patients, and all of them areUighurs,the prevalence of PD in the region is1.48%over the age of45,and therein1.68%of men and1.28%of women. The prevalent of PD in the age of45-54,55-64,65-74,75-84,85-94years old and≥95-year-olds were0.55%,1.38%,2.28%,3.11%,4.41%and4.17%. The standardized prevalence of PD in hetian,Xinjiang is1.32%as the standardized of The Fifth Population Census in China. Single factor results show that: α=0.05, to partici-pate in the exercise, social activities (χ~2=17.59, P＜0.05, OR=0.21,95%CI0.10-0.44),eat nuts frequently(χ~2=6.03, P＜0.05, OR=0.43,95%CI0.22-0.84) were the protectivefactors for PD; and the history of pesticide exposure (χ~2=114.56, P＜0.05, OR=3.21,95%CI1.76-5.85), the family history of PD (χ~2=3.98, P＜0.05, OR=3.67,95%CI1.02-13.14), barbecue (χ~2=4.80, P＜0.05, OR=2.50,95%CI,1.10-5.68) were risk factors forPD occurred. Multi-factor conditional logistic regression analysis showed that: for sports,social activities (B=-1.60, χ~2=13.60, P＜0.05, OR=0.20,95%CI,0.09-0.47) can reducethe risk of PD; and pesticide exposure history (B=1.05, χ~2=7.87, P＜0.05, OR=2.85,95%CI,1.37-5.91), PD family history (B=1.83, χ~2=5.21, P＜0.05, OR=6.21,95%CI,1.30-29.80) increases the risk of PD; but barbecue, nuts and the family history of PD have nosignificant correlation with PD. Conclusion: PD is the result of the interaction of manyfactors, to participate in the exercise and social activities is the protective factors for PD,and PD masculine family history and the history of pesticide exposure is a risk factor forPD.