| Purpose:Observation the clinic efficacy of the treatment of primary insomnia by TIP sleeps regulation and control technology with drug.Method:Divide92patients with primary insomnia in Guang’an Men hospital (sleep thematic outpatient) for treatment into Chinese medicine group, western medicine group, Chinese medicine plus psychotherapy group and western medicine plus psychotherapy group. Patients in Chinese medicine group boiled-water-granules Wen Dan Ning Xin grain,6g once and3times a day. Patients in western medicine group taking1-2Estazolam Tablets half an hour before sleeping, their dose will be adjustment according to the disease. Patients in Chinese medicine plus psychotherapy group will be treatment by TIP sleeps regulation and control technology in addition to taking boiled-water-granules Wen Dan Ning Xin grain. Patients in western medicine plus psychotherapy group will be treatment by TIP sleeps regulation and control technology in addition to taking Estazolam Tablets. All the patients’PSQI, SPEIGEL and symptom will be measured before they join the group and leave the group a month later.ResultA. Pittsburgh Sleep Quality Index (PSQI)Comparison among groups:Traditional Chinese medicine plus psychological group is better than western medicine group after comparing PSQI total score between two groups, and the difference is statistically significant (P<0.013); The quality factor in sleep of western medicine plus psychological group is better than western medicine group by comparing factor scores in PSQI between groups(P<0.013).Comparisons within group:Western medicine group have improvement compared with the situation before treatment, but the results is not statistically significant (P>0.05). There are improvement in other three groups, and the results is statistics significance (P<0.05); Comparing sleep quality and hypnotic drugs factor score in western medicine group, the result is improved and has statistics significance (P<0.05). The sleep quality, sleep efficiency and daytime function are improved in traditional Chinese medicine plus psychological group, and the results have statistics significance (P<0.05). The sleep quality, sleep disorders and daytime function are improved in traditional Chinese medicine group, and the results have statistics significance (P<0.05). The sleep quality and sleep disorders are improved in western medicine plus psychological group, and the results have statistics significance (P<0.05).2. SPIEGEL IndexComparison among groups: Comparing reduced rate difference of SPIEGEL total score before and after treatment, the results have statistics significance (P<0.05). While comparing two groups, western medicine plus psychological group is better than western medicine group, the traditional Chinese medicine group is better than western medicine group, and traditional Chinese medicine plus psychological group is better than western medicine group(P<0.05); The wake up feeling has statistics significance when comparing among groups (P<0.05). The western medicine plus psychological group is better than western medicine group. The traditional Chinese medicine plus psychological group is better than western medicine group (P<0.013).Comparisons within group:The results is improved but has not statistics significance when compared in western medicine group, the SPIEGEL total score are improved and have statistics significance in other three groups(P<0.05).When comparing within group, the bedtime and total sleep time of patients in western medicine group are improved and the results have statistics significance (P<0.05); The number of night waking, sleep depth, and wake up feeling of patients in traditional Chinese medicine plus psychological group are improved and the results have statistics significance (P<0.05); The sleep time, dream, and wake up feeling of patients in traditional Chinese medicine group are improved and the results have statistics significance (P<0.05); The bedtime, total sleep time, night wakeup frequency, deep of sleep and wake up feeling of patients in western medicine group are improved and the results have statistics significance (P<0.05).3. Symptoms total score of deficiency insomnia of heart and gall Comparison among groups:Comparing the symptoms total score of deficiency insomnia of heart and gall between groups before and after treatment, the difference and reduced rate have not statistics significance(P>0.05); Timid and easily frightened of the western medicine plus psychological group is better than the traditional Chinese medicine group when comparing between groups (Pv0.013).Comparisons within group:When comparing in group before and after treatment, the traditional Chinese medicine plus psychological group and the western medicine plus psychological group are improved and have statistics significance (P<0.05). The comparison of symptom score efficiency of the traditional Chinese medicine plus psychological group is better than the western medicine group, and the difference has statistics significance;When comparing in group, Fatigue of patients in the western medicine group is improved and has statistics significance (P<0.05). Timid and easily frightened, insomnia, dreams and fatigue of the traditional Chinese medicine plus psychological group are improved and have statistics significance (P<0.05). The insomnia and fatigue of the traditional Chinese medicine group are improved and have statistics significance (P<0.05). Timid and easily frightened, insomnia, dreams, palpitations and fatigue of the western medicine plus psychological group are improved and have statistics significance (P<0.05).Conclusion1. This study suggests four kinds of intervention methods for primary insomnia has improved in different degrees. Four kinds of intervention methods on the PSQI scale of sleep quality factor score and symptom score weakness factor scores have improved. The results suggest that doctors in clinic can vary according to the actual situation of different intervention methods, in order to improve patient compliance and treatment methods of diversity.2. This study suggests that the drug combined with psychological intervention methods in clinical is more effective than simply using drug intervention. This research shows that drug combined with psychological intervention methods is better thansimple drug group on PSQI Scale total score, PSQI scale sleep quality factor,symptom score rate,symptom score skittish factor score. The results suggest that clinicians in treating of primary insomnia drug combined with psychological intervention when chousing the method. It can receive better effect.3. This study shows the western medicine group were the worst inside three groups, and loss rate is the highest, but the results are not suggested in clinical medicine is not recommended for use.Because of the limitations of the study, the above conclusion needs further studies. |
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