A Study Of~1H-magnetic Resonance Spectroscopy On Bilateral Thalamus Of Patients With Partial And Secondarily Generalized Seizures

Objective To study the changes of metabolites in the bilateral thalamus of patients with CPS/SPS and SGC, in order to explore the possible mechanism of SGC.Methods Fifteen patients with CPS/SPS and SGC, fifteen matched healthy volunteers were studied by’HMRS. The levels of metabolites including NAA、Cho、Cr-PCr、ml of the bilateral thalamus were measured and compared among these three groupes.Results The ratios of NAA/Cr-PCr、NAA/(Cr-PCr+Cho) in the left thalamus of CPS/SPS and SGC group were1.7220±0.09810.9651±0.5758and1.7653±0.1919、1.0000±0.9944respectively.There were no differences between the two (P>0.05),but were significantly lower than that in the control group (1.9140±0.1204、1.0901±0.8443)(P<0.05); The ratios of NAA/Cr-PCr. NAA/(Cr-PCr+Cho) in the right thalamus of CPS/SPS and SGC group were1.7353±0.1256、0.9664±0.0768and1.7973±0.2286、0.9995±0.1249respectively.There were also no differences between the two(P>0.05),but were significantly lower than that in the control group (1.9453±0.1527、1.1050±0.9970)(P<0.05) too; The ratios of Cho/Cr-PCr, mI/Cr-PCr in the bilateral thalamus of these three groups in two-two comparison, there were no differences (P>0.05). Conclusions1.The bilateral thalamus in patients with CPS/SPS and SGC may have neuronal dysfunction.2.This study failed to find the conographical evidence that bilateral thalamus had took part in the epileptogenesis of SGC by using1HMRS. it still needs to accumulate more materials.