Clinical And Eental Stclinicxperimudy Of The Bushen Huazhuo Fang On Peventing And Treating NAFLD Of Kidney Yin Deifciency

Objective: To observe the clinical efficiency of Bushen Huazhuo Fang on treatingkidney yin deficiency type non-alcoholic fatty liver and through the research on the side ofrats fed by high fat forage experimental research to investigate its mechanism of action.Methods: The clinical study:60patients with nonalcoholic fatty liver of Kidney yindeficiency were randomly divided into treatment group and control group,each group has30patients. The treatment group received Bushen Huazhuo Treatment, and the controlgroup was given silybin capsules. After12weeks of treatment, observe the symptoms,liverchemistry,blood lipids, results of ultrasonic wave of B-type before and after the treatment,for statistical analysis.Experimental research:45Wistar rats were randomly divided into blank group, modelgroup, silybin capsules group and Bushen Huazhuo group, the blank group was fed withnormal diet, model group, silybin capsules, Bushen Huazhuo group was fed with the highfat diet.Silybin capsules and the Bushen Huazhuo group were fed with the correspondingdrug.After12weeks, rats were sacrificed, calculate the rat liver index, Lee’s index, insulinresistance index, insulin sensitivity index, detect liver chemistry, blood lipids, bloodglucose, insulin, leptin and tumor necrosis factor and liver pathology.Results: The clinical study: after treatment, two groups patients have significantlyimproved than before in the symptom score, liver chemistry, results of B-type ultrasonic(P<0.05or P <0.01),Bushen Huazhuo group was significantly better than the control group intotal efficacy, the clinical synthetic curative effect, TG(P <0.05or P <0.01); there was nosignificant difference on liver chemistry,results of B-type ultrasonic between two groups(P>0.05).Experimental research:Bushen Huazhuo group, Silybin group could significantlyimprove the ALT, AST, LEP(P <0.01);the Bushen Huazhuo group was better than Silybingroup on improving INS, IRI, ISI(P <0.05or P <0.01),Silybin group has no significanteffection on improving INS and IRI(P>0.05), Silybin group, the Bushen Huazhuo groupwere better than the model group in fat stain, glycogen stain(P <0.05or P <0.01).Conclusion: The Bushen Huazhuo group can effectively treat non-alcoholic fattyliver, and has obvious advantages on improving clinical symptoms, TG level,it has thesame capacity on improving liver chemistry,results of B-type ultrasonic,the total effect isbetter than Silybin group.Fatty liver rats have significant leptin resistance and insulin resistance; Silybin and theBushen Huazhuo Fang can effectively intervene inflammation of the liver caused by highfat diet, the Bushen Huazhuo group has advantages on decreasing LEP, INS and IRIcompared with silybin capsules. Silybin group and Bushen Huazhuo group have almost thesame effect on improving adipocytes stain and glycogen stain.Bushen Huazhuo Fangremedy the NAFLD by protecting liver, regulating blood fat, improving leptin resistance,improving insulin resistance.