Clinical Observation Of Combined Therapy Using Modified Shou Tai Wan And Western Medicine For Treating Early Threatened Abortion With Sub-chorionic Haematoma In In Vitro Fertilisation Pregnancy.

Purpose: To analyse relevant factors which affect early threatened abortion (ETA)with sub-chorionic haematoma (SCH) in early in vitro fertilisation-embryo transfer (IVF)pregnancy, and to observe the clinical efficacy of combined therapy using modified ShouTai Wan and western medicine in treating it.MethodFirst Part: To collect data of60hospitalised and outpatient samples which arediagnosed with ETA with SCH at the Department of Gynaecology, Shandong University ofTraditional Chinese Medicine Affiliated Hospital between January2010and February2012.Amongst them,30samples are categorised as IVF group; the other30are non-IVF group.These samples are then analysed and compared for the patients’s ages, their gestationalages, the total number of natural miscarriages, the onset timing of vaginal bleedings, theduration of vaginal bleedings, the SCH area, the proportion of SCH area and gestationalsac area, and the blood serum level of β-Human chorionic gonadotrophin (β-hCG),Estradiol (E2) and Progesterone (P). This is to investigate factors which might be relevantto ETA with SCH in early IVF pregnancy.Second Part: To collect68hospitalised and outpatient samples which fit into thedefined standards of IVF pregnancy at the Department of Gynaecology, ShandongUniversity of Traditional Chinese Medicine Affiliated Hospital between January2010andFebruary2012, and separate them into two groups according to the following conditions:group A,20-30years old,33samples; group B,31-40years old,35samples. Thesesamples are then prescribed with the combined therapy of modified Shou Tai Wan and western medicine to observe its clinical efficacy of treating ETA with SCH in IVFpregnancy. Observations include:1. Improvement of the cumulative number compiledfrom soreness and weakness at waist and knees, sagging and pain in lower abdomen,dizziness and tinnitus, frequent nocturnal micturition, blackened eye socket, etc. All ofwhich are symptoms of kidney deficiency in Chinese medicine diagnosis.2. Changes inthe SCH area, the proportion of SCH area and gestational sac area, as well as the bloodserum level of β-hCG, E2and P before and after treatment.Results1.There is a significant difference (P<0.01) between the IVF group and the non-IVFgroup in terms of age, gestational age, the onset timing of vaginal bleeding, the proportionof SCH area and gestational sac area, and the blood serum level of E2and P after42daysand56days of amenorrhea. There is also an obvious difference (P<0.05) between the twogroups in terms of the duration of vaginal bleeding and the blood serum level of β-hCGafter56days of amenorrhea. However, no obvious distinction (P>0.05) is observedbetween the IVF group and the non-IVF group in terms of the total number of naturalmiscarriages, the SCH area and β-hCG level in blood serum after42days of amenorrhea.2.The efficacy of the combined therapy of modified Shou Tai Wan and westernmedicine as a treatment for ETA with SCH in IVF pregnancy is80.88%. There is asignificant difference (P<0.01) in the SCH area, SCH area and gestational sac area and thekidney deficiency symptoms diagnosed by Chinese medicine before and after the treatment.When comparing the efficacy, the SCH area, the proportion of SCH area and gestationalsac area, and the cumulative number generated from symptoms of kidney deficiency in theChinese medicine, group A and group B show significant difference (P<0.01) betweenthem following the combined therapy. However, no obvious distinction (P>0.05) in theblood serum level of β-hCG, E2, P after56days of amenorrhea is observed between groupA and group B.Conclusion1.ETA with SCH in IVF pregnancy is related to a patient’s age, gestational age, theonset timing of vaginal bleeding, the duration of vaginal bleeding, the blood serum level ofE2and P42days after amenorrhea, and the blood serum level of β-hCG, E2and P56dayssince amenorrhea.2.The combined therapy of modified Shou Tai Wan and western medicine couldeffectively improve the kidney deficiency symptoms, the SCH area, the proportion between SCH area and gestational sac area, and the blood serum level of β-hCG, E2and Pof a patient who suffers from ETA with SCH in IVF pregnancy. It is even more effective inimproving the cumulative number generated from symptoms of kidney deficiency in theChinese medicine, the SCH area, and the proportion between SCH area and gestational sacarea of patients who are aged between20-30years old.