Tiao He Yin To Er(+)Pr(+)and Her-2(-) Breast Cancer By Tamoxifen The Rapy For Patients After The Influence Of Bone Density

objectivesStudy on the traditional Chinese medicine self tiao he yin on tamoxifen therapy for breast cancer cause osteoporosis influence. the effects of the traditional Chinese medicine participation observation-breast cancer prevention and control related bone loss in effect whether there are inhibition caused by TAM bone loss and endocrine disorders brought about by the series of comprehensive syndrome, then explain and provide Chinese medicine in prevention of breast cancer consolidate adjuvant endocrine therapy caused by the related adverse reaction mechanism of action and assess efficacy of objective evidence.Methods1select60cases estrogen positive (ER+) progesterone positive (PR+) human epidermal growth factor-2negative [Her-2(-)], kno wn as breast cancer patients underwent surgery or radiation and chemotherapy and has started to sequential therapy patients taking TAM.260patients with breast cancer patients were randomly divided into the treatment group and control group, each group of each30people, observation and treatment time for half a year. The treatment group:the drugs TAM adds the Chinese native, the control group:the simple drugs TAM. Observe and contrast in two groups before and after treatment were in bone mineral density and bone metabolism markers TAM of incretion disorders and cancer patients Karnofsy score changes, and adverse drug reactions and safety problems. 3All analysis data are used spss16.0package processing, count material using a chi-square test, measurement data using t-test, level material using rank and inspection.Results1After test treatment group than in control group to improve bone mineral density, the comparison of the two groups (P<0.05). chinese traditional medicine to help improve with breast cancer patients osteoporosis degree, enhancing the lumbar spine and femoral nearly to the bone density. The control group simply use TAM before and after the experiment the lumbar spine and proximal femur bone mineral density contrast P>0.05that, alone without TAM take Chinese traditional medicine, TAM can make a further decline or slow bone mineral density decline.2In two groups before and after test cases of contrast, bone metabolism index PINP, beta CTX for comparison between the two groups before and after (P<0.05) have statistical significance, add with Chinese traditional medicine group can inhibit the bone loss caused by TAM, improve bone density, main is to promote bone formation, to inhibit bone absorption also have certain effect.3The treatment group of traditional Chinese medicine clinical symptom scores have significantly improve patients with clinical symptoms and signs, add with Chinese traditional medicine group curative effect is better than pure western medicine group, the comparison of traditional Chinese medicine clinical medicine in the way before and after the symptom score (P<0.05), indicating that pure with tamoxifen group, the clinical symptoms, signs before they get better and be serious trend.4After test control group and the treatment group KPS score by inspection patients with contrast P<0.05. difference was statistically significant. And with that with Chinese traditional medicine after drinking may have patients improve bone mineral density, can improve the quality of survival, the clinical symptoms is obviously alleviate clinical benefit patients.5Safety index determination of liver and kidney function has not seen the obvious toxic effect.conclusion1Traditional chinese medicine self tiao he yi to through filling kidney nourishing the liver and invigorating spleen for the treatment principle, fill in the kidney essence of bones and treat breast cancer TAM caused by osteoporosis has inhibitory effect. Clinical research that it can promote bone formation and can strengthen bone calcium deposits. To inhibit bone metabolism enhancement (inhibit bone absorption) role is not strong.2Traditional Chinese Medicine Tiao he yin to breast cancer patients endocrine disorders accompanied by upset muggy night sweats, insomnia, joint aching muscles and clinical symptoms good of treatment and soothing effects.3Traditional Chinese medicine tiao he yin drug use,drug dosage forms, dose when were in prevention and cure breast cancer patients osteoporosis that caused by TAM with safe, did not see such as liver and kidney and side effects. 4Traditional Chinese medicine tiao he yin through in the overall effect of the kidney method can adjust the breast cancer patients in enhancing immunity of body environment to improve the quality of survival, but whether to breast cancer patients live a longer effect, due to restrictions and can’t reason such as the long-term follow-up is unknown, need to be in clinical further proved.