Chemical Constituents Of Two Medical Plants

Two medicinal plants, Allium sativum and Dysosma versipellis, have been chemically investigated. A total of28compounds were obtained, and with the help of extensive spectroscopic data, they were characterized as two nor-sesquiterpenes, six tyramines, seven flavones, nine lignans, two aromatic compounds, and one steroidal compounds.Two nor-sesquiterpenes and six tyramines were isolated from the leaves of A. sativum. Their structures were established with the help of extensive spectroscopic (MS, NMR) data analysis and data reported in the literature. Among all the compounds obtained, compounds1-6and8were isolated from the species of A. sativum for the first time. Antitumor and antifungal activities of compounds1-8were tested, and the results were negative.Seven flavones and nine lignans were isolated from the roots of D. versipellis. On the basis of spectroscopy methods and data reported in literature, their structure were established. With the help of DPPH scanvenging test and Fe2+ione chelating test, antioxidant activities of three flavones were tested, and compound14showed most potent activities, which suggested it may possess some pharmacological effects based on antioxidant activity. Antitumor activities of isolated lignans were tested and compound17showed most inhibitory activities to A172and MD-MBA-231with IC50value of21.04μM and2.12μM, respectively.