| ObjectiveTo explore the correlation between the circulationg level of growth differentiationfactor-15and coronary heart disease (CHD), and its role for risk stratification in CHD.MethodsChoose the inpatients who underwent coronary angiography as the research objects,including sixty-one patients with acute myocardial infarction (AMI), forty-one withstable angina pectoriso (SAP), and forty with no cardiovascular disease evidence cohort.Collect baseline characteristics of all patients, including age, gender, body mass index, etal, and their blood specimens. Then biochemical markers of all patients were detected inour hospital laboratory. But the circulating level of GDF-15was measured by ELISAalone. Count the number of diseased vessels and Gensini score according to the results ofcoronary angiography. First, the concentration of GDF-15, hs-CRP, NT-proBNP incontrol, SAP and AMI group were analyzed. Secend, the relationship between thenumber of diseased vessels (or Gensini score) and the levels of GDF-15, hs-CRP,NT-proBNP were expored respectively. Last, the correlations between GDF-15andclinical risk indicators or risk biomakers in CHD were investigated.Result1. The level of GDF-15of group AMI was significantly higher than those in the groupSAP (P<0.01) and control group（P<0.01）. Group SAP compared with control group hadno significant difference (P>0.05).2. The level of serum GDF-15was dramaticly increased in multivessel disease group(group M) than duble-vessel disease group (group B)(P=0.001) and single-vessel group(group S)(P <0.001). Group B compared with group S had no significant difference (P>0.05).3. The level of serum GDF-15was elevated by the rising of Gensini score, andsignificant differences in mean GDF-15levels were found between the group A and group C (P<0.05).4. The level of hs-CRP for group AMI was significantly higher than those in the groupSAP (P<0.05)and control group (P<0.001). Group SAP compared with control grouphad no significant difference (P>0.05).5. No significant differences in mean (or median) hs-CRP levels were found among thedifferent diseased vessels group (group M、B and S), as well as among the differentGensini score group.6. The level of NT-proBNP of group AMI was significantly higher than those in thegroup SAP (P<0.001) and control group (P<0.001). Group SAP compared with controlgroup had no significant difference (P>0.05).7.Significant differences in mean NT-proBNP levels were found between the group Mand group B (P=0.001), as well as between group M and group S (P<0.001), Thegroup B compared with group S had no significant difference.8. The level of NT-proBNP was elevated by the rising of Gensini score, and the levelsof NT-proBNP of group C and group B were significantly higher than those in the groupA, respectively (P<0.05).9.Bivariate correlation analysis showed that increased levels of GDF-15wereassosiated with body mass index, triglycerides, systolic pressure, WBC, low HDLcholesterol. There are no assosiation between GDF-15and age, Fasting glucose and lowLDL cholesterol, Total cholesterol.By multiple regression analysis that used the GDF-15as the independent variable,GDF-15was independently associated with the levels of CK-MB, hs-CRP, hs-TnT, andNT-proBNP, both in patients with SAP or with AMI（P<0.01）.ConclusionThe circulationg levels of GDF-15were significantly higher than those in the SAPand control group, further analysis showed that GDF-15was independently assosiatedwith clinical risk indicators, myocardial injury biomakers and Inflammatory makers. Thelevels of GDF-15and NT-proBNP were also closely associated with the number ofdiseased vessels and Gensini score. Increasing levels of GDF-15were independently and positively associated with NT-proBNP, hs-CRP, CK-MB, hs-TnT, to a certain extent,GDF-15reflect the acute myocardial ischemia and injury. The study demonstrates thatthe GDF-15is a potential tool for risk stratification in CHD and diagnosis in acutemyocardial infarction as a biomarker. |
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