The Association Between SNPs In Vav2and Vav3and Mmp-9and The Onset Of PACG In Chinese Han Population

Purpose: To examine the association between the single nucleotidepolymorphisms (SNPs) in Vav2and Vav3and matrix metalloprotease-9(MMP-9) gene and primary angle-closure glaucoma (PACG) in a ChineseHan population.Methods: A case-control analysis was performed in214PACG patients and224sex-, and ethnical-matched healthy controls. These six SNPsrs2156323(Vav2) and rs2801219（Vav3）and rs3918249, rs3918254,rs17577and rs3787268in MMP-9were genotyped using polymerase chainreaction restriction fragment length polymorphism (PCR-RFLP) assay. Theassociation between these genetic polymorphisms and risk of PACG wasestimated by χ2.Results: All genotype distributions in healthy controls were inHardy–Weinberg equilibrium (HWE, p>0.05). The increased frequency ofCC and CT genotype of rs3918254was observed in PACG patientscompared with healthy controls (P=0.006, P corrected (Pc)=0.048). Thehaplotype analysis showed that the CCGG haplotype was nominal associated with PACG (P=0.015), however, the significant was lost whenthe Bonferroni correction was used (Pc=0.105). Allelic and genotypicfrequency analysis of other SNPs revealed no significant differencebetween patients with PACG and healthy controls.Conclusions: Our results revealed that rs3918254in MMP-9may be thesusceptible SNP to Chinese PACG patients, people with the CC and CTgenotype of rs3918254are more likely to get PACG. The susceptibility toPACG in Chinese Han patients may be not influenced by SNPs rs3918249,rs3787268, rs17577in MMP-9and rs2156323(Vav2) and rs2801219(Vav3). The Vav2and Vav3may be not the susceptible genes for PACG inChinese Han population.