The Clinical Reserch Of Kidney And-liver Nourishing Cooperated With Progesterone In The Trimester Threatened Abortion Patient With The Kidney Deficieney And Liver Depressed

Purpose:To observe the clinical efficacy of theray in the way of nourishing kidney and Liver with progesterone, as well as discuss the mechanism of it.Meanwhile to Investigate the TNF-α,IL-8and threatened abortion, and to provide clinical treatment.Method:Separate forty seven patients of clinic and ward into either treatment or control group randomly. Twenty-one cases among the control group are given twenty milligram progesterone intramuscular injection per day. The patients of treatment group are also given the same amount of progesterone, but using the tradition Chinese meditine cooprate in addition for treatments. The course of each treatment is four weeks. We observe both groups for one course of treatment. The observation are based on the improvement of main symptoms, levels of E2、P、β-HCG、TNF-α, and IL-8of both groups patients before and after medications.Consequence:Determined the treatment efficiency according to symptoms accumulate points:Treatment group:Recovery rate7.69percent, markedly improvement rate76.93percent, valid rate7.69percent, invalid rate7.69percent, overall valid rate92.31percent. Control group: Recovery rate0percent, markedly improvement rate57.14percent, valid rate28.57percent, invalid rate14.29percent, the total valid rate85.71percent. Through the rank-sum test (P<0.05), it is found that the treatment efficiency of treatment group are better. The symptoms accumulate points for both groups are decreased after treatments. The difference has made statistical significant through test. The difference of symptoms accumulate points for both groups before and after treatment has made statistical significant through test (P<0.05) as well. The difference of treatment group is larger than control. Tt shows that the treatment efficiency of treatment group is better. The levels of Serum E2、P、β-HCG for both groups after treatment are higher than before treatment. The differences between sex hormone before and after treatment has statistical significant through test (P<0.05). The difference of treatment group is larger than control group, it shows that it has advantage on improvement of sex hormone. The two groups of serum TNF-a, IL-8are decreased by the test, the difference is statistically significant (P<0.05), indicating that both groups of TNF-a, IL-8in a downward trend. The difference before and after treatment of TNF-a, IL-8is statistically significant (P<0.05), the difference of the treatment group is lager than the control group, indicating that the treatment group in reducing the level of TNF-a, IL-8is better than the control group. The serum TNF-α, IL-8of successful groups is decreased (P<0.05), the serum TNF-a, IL-8of miscarriage has no significant change (P>0.05).Conclusion:The herbal therapy in the way of nourishing kidney and liver with progest--erone for first-trimester threatened abortion clearly improve the symptoms of vaginal bleeding, abdominal pain and soreness of waist etc. This treatment also improves the levels of E2, P and (β-HCG. and decreases the levels of TNF-α, and IL-8. Bu Kidney and-Liver Nourishing treatment is a valid method on ameliorate the symptoms of incipient abortion patients and regulation of endocrine function. Monitoring of serum TNF-α, IL-8is valuable in Clinical Practice in the prediction of pregnancy outcome of threatened abortion.